BPIFA1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BPIFA1 at tissue level.

III. Associated gene sets

GO_1900229Biological processnegative regulation of single-species biofilm formation in or on host organism
GO_0051607Biological processdefense response to virus
GO_0061844Biological processantimicrobial humoral immune response mediated by antimicrobial peptide
GO_0019731Biological processantibacterial humoral response
GO_0050891Biological processmulticellular organismal-level water homeostasis
GO_0002395Biological processimmune response in nasopharyngeal-associated lymphoid tissue
GO_0043129Biological processsurfactant homeostasis
GO_1902305Biological processregulation of sodium ion transmembrane transport
GO_0045087Biological processinnate immune response
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0005515Molecular functionprotein binding
GO_0008289Molecular functionlipid binding
GO_0003674Molecular functionmolecular_function

IV. Literature review

[source]
Gene nameBPIFA1
Protein nameBPI fold-containing family A member 1 (Lung-specific protein X) (Nasopharyngeal carcinoma-related protein) (Palate lung and nasal epithelium clone protein) (Secretory protein in upper respiratory tracts) (Short PLUNC1) (SPLUNC1) (Tracheal epithelium-enriched protein) (Von Ebner protein Hl)
SynonymsPLUNC
SPURT
LUNX
NASG
UNQ787/PRO1606
SPLUNC1
DescriptionFUNCTION: Lipid-binding protein which shows high specificity for the surfactant phospholipid dipalmitoylphosphatidylcholine (DPPC) . Plays a role in the innate immune responses of the upper airways . Reduces the surface tension in secretions from airway epithelia and inhibits the formation of biofilm by pathogenic Gram-negative bacteria, such as P.aeruginosa and K.pneumoniae . Negatively regulates proteolytic cleavage of SCNN1G, an event that is required for activation of the epithelial sodium channel (ENaC), and thereby contributes to airway surface liquid homeostasis and proper clearance of mucus . Plays a role in the airway inflammatory response after exposure to irritants . May attract macrophages and neutrophils . .

AccessionsENST00000375413.8 [Q9NP55-1]
ENST00000354297.9 [Q9NP55-1]
ENST00000375422.6 [Q9NP55-1]
Q9NP55