BATF2 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of BATF2 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of BATF2 at tissue level.

III. Associated gene sets

GO_0140467Biological processintegrated stress response signaling
GO_0042832Biological processdefense response to protozoan
GO_0043011Biological processmyeloid dendritic cell differentiation
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0090575Cellular componentRNA polymerase II transcription regulator complex
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0005515Molecular functionprotein binding
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific

IV. Literature review

[source]
Gene nameBATF2
Protein nameBasic leucine zipper transcriptional factor ATF-like 2 (B-ATF-2) (Suppressor of AP-1 regulated by IFN) (SARI)
Basic leucine zipper ATF-like transcription factor 2
Basic leucine zipper ATF-like transcription factor 2 (cDNA FLJ54822)
Synonyms
DescriptionFUNCTION: AP-1 family transcription factor that controls the differentiation of lineage-specific cells in the immune system. Following infection, participates in the differentiation of CD8(+) thymic conventional dendritic cells in the immune system. Acts via the formation of a heterodimer with JUN family proteins that recognizes and binds DNA sequence 5'-TGA[CG]TCA-3' and regulates expression of target genes (By similarity). Selectively suppresses CCN1 transcription and hence blocks the downstream cell proliferation signals produced by CCN1 and inhibits CCN1-induced anchorage-independent growth and invasion in several cancer types, such as breast cancer, malignant glioma and metastatic melanoma. Possibly acts by interfering with AP-1 binding to CCN1 promoter. .

AccessionsB4DV37
ENST00000435842.2 [Q8N1L9-2]
ENST00000301887.9 [Q8N1L9-1]
Q8N1L9
ENST00000527716.1
ENST00000534177.1
E9PJ73