I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 23% ± 4% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| epithelial cell | 4 studies | 23% ± 4% |
Insufficient scRNA-seq data for expression of BAP1 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 6056.84 | 1445 / 1445 | 100% | 52.89 | 183 / 183 |
| skin | 100% | 7522.32 | 1809 / 1809 | 100% | 101.80 | 472 / 472 |
| thymus | 100% | 6616.96 | 653 / 653 | 100% | 62.71 | 605 / 605 |
| brain | 100% | 9555.00 | 2640 / 2642 | 100% | 99.04 | 705 / 705 |
| pancreas | 100% | 3509.74 | 327 / 328 | 100% | 51.97 | 178 / 178 |
| lung | 100% | 6008.82 | 578 / 578 | 100% | 56.44 | 1151 / 1155 |
| stomach | 100% | 4603.96 | 359 / 359 | 100% | 50.16 | 285 / 286 |
| breast | 100% | 5599.76 | 459 / 459 | 100% | 61.91 | 1114 / 1118 |
| prostate | 100% | 6408.67 | 245 / 245 | 100% | 66.59 | 500 / 502 |
| adrenal gland | 100% | 7202.07 | 258 / 258 | 100% | 59.25 | 229 / 230 |
| ovary | 100% | 5318.94 | 180 / 180 | 100% | 55.69 | 428 / 430 |
| bladder | 100% | 5654.62 | 21 / 21 | 99% | 57.06 | 500 / 504 |
| intestine | 100% | 5904.59 | 966 / 966 | 99% | 55.43 | 522 / 527 |
| kidney | 100% | 5826.88 | 89 / 89 | 99% | 50.64 | 892 / 901 |
| uterus | 100% | 5527.14 | 170 / 170 | 99% | 66.57 | 454 / 459 |
| liver | 100% | 3880.81 | 226 / 226 | 99% | 46.25 | 400 / 406 |
| adipose | 100% | 5431.56 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 72.62 | 29 / 29 |
| muscle | 100% | 5687.07 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 6594.94 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 73.98 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 32.00 | 1 / 1 |
| blood vessel | 100% | 5730.04 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| heart | 99% | 3762.26 | 850 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 97% | 4177.15 | 902 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 90% | 68.32 | 72 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0071108 | Biological process | protein K48-linked deubiquitination |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0000278 | Biological process | mitotic cell cycle |
| GO_0030223 | Biological process | neutrophil differentiation |
| GO_0001558 | Biological process | regulation of cell growth |
| GO_0001701 | Biological process | in utero embryonic development |
| GO_0043249 | Biological process | erythrocyte maturation |
| GO_0033028 | Biological process | myeloid cell apoptotic process |
| GO_0006511 | Biological process | ubiquitin-dependent protein catabolic process |
| GO_0035520 | Biological process | monoubiquitinated protein deubiquitination |
| GO_0002574 | Biological process | thrombocyte differentiation |
| GO_0050727 | Biological process | regulation of inflammatory response |
| GO_0006338 | Biological process | chromatin remodeling |
| GO_0061484 | Biological process | hematopoietic stem cell homeostasis |
| GO_0070050 | Biological process | neuron cellular homeostasis |
| GO_0070661 | Biological process | leukocyte proliferation |
| GO_1900015 | Biological process | regulation of cytokine production involved in inflammatory response |
| GO_0036211 | Biological process | protein modification process |
| GO_0043363 | Biological process | nucleate erythrocyte differentiation |
| GO_0061519 | Biological process | macrophage homeostasis |
| GO_0036344 | Biological process | platelet morphogenesis |
| GO_0016579 | Biological process | protein deubiquitination |
| GO_0035726 | Biological process | common myeloid progenitor cell proliferation |
| GO_1903955 | Biological process | positive regulation of protein targeting to mitochondrion |
| GO_0010467 | Biological process | gene expression |
| GO_0001894 | Biological process | tissue homeostasis |
| GO_0045892 | Biological process | negative regulation of DNA-templated transcription |
| GO_0051726 | Biological process | regulation of cell cycle |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0035517 | Cellular component | PR-DUB complex |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0140950 | Molecular function | histone H2A deubiquitinase activity |
| GO_0004843 | Molecular function | cysteine-type deubiquitinase activity |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0031490 | Molecular function | chromatin DNA binding |
| GO_0005515 | Molecular function | protein binding |
| Gene name | BAP1 |
| Protein name | Ubiquitin carboxyl-terminal hydrolase BAP1 (BRCA1-associated protein 1) Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) Ubiquitin carboxyl-terminal hydrolase BAP1 (EC 3.4.19.12) (BRCA1-associated protein 1) (Cerebral protein 6) Ubiquitin carboxyl-terminal hydrolase (EC 3.4.19.12) BRCA1 associated protein 1 (Cerebral protein-13) |
| Synonyms | KIAA0272 hucep-13 hucep-6 |
| Description | FUNCTION: Deubiquitinating enzyme that plays a key role in chromatin by mediating deubiquitination of histone H2A and HCFC1 . Catalytic component of the PR-DUB complex, a complex that specifically mediates deubiquitination of histone H2A monoubiquitinated at 'Lys-119' (H2AK119ub1) . Does not deubiquitinate monoubiquitinated histone H2B . Acts as a regulator of cell growth by mediating deubiquitination of HCFC1 N-terminal and C-terminal chains, with some specificity toward 'Lys-48'-linked polyubiquitin chains compared to 'Lys-63'-linked polyubiquitin chains . Deubiquitination of HCFC1 does not lead to increase stability of HCFC1 . Interferes with the BRCA1 and BARD1 heterodimer activity by inhibiting their ability to mediate ubiquitination and autoubiquitination . It however does not mediate deubiquitination of BRCA1 and BARD1 . Able to mediate autodeubiquitination via intramolecular interactions to couteract monoubiquitination at the nuclear localization signal (NLS), thereby protecting it from cytoplasmic sequestration . Acts as a tumor suppressor . . |
| Accessions | ENST00000460680.6 ENST00000469613.5 ENST00000478368.1 Q92560 H7C4V7 A0A4V1DYV2 ENST00000470173.1 C9J7L9 ENST00000615113.1 H0Y8E8 ENST00000490917.1 ENST00000296288.9 F8W6N3 A0A346RV25 Q96TC6 F8WEY5 |
