Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| oligodendrocyte | 14 studies | 34% ± 11% | |
| retinal cone cell | 5 studies | 31% ± 8% | |
| neuron | 4 studies | 28% ± 12% | |
| endothelial cell | 4 studies | 21% ± 5% | |
| GABAergic neuron | 4 studies | 42% ± 14% | |
| astrocyte | 4 studies | 22% ± 6% | |
| glutamatergic neuron | 4 studies | 46% ± 14% | |
| fibroblast | 3 studies | 17% ± 1% | |
| oligodendrocyte precursor cell | 3 studies | 29% ± 5% | |
| interneuron | 3 studies | 41% ± 20% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| brain | 7 studies | 36% ± 14% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 100% | 5878.93 | 2637 / 2642 | 100% | 33.14 | 703 / 705 |
| ovary | 100% | 4200.57 | 180 / 180 | 98% | 16.17 | 422 / 430 |
| prostate | 100% | 2462.63 | 244 / 245 | 98% | 8.05 | 492 / 502 |
| adrenal gland | 100% | 3343.38 | 258 / 258 | 95% | 13.50 | 219 / 230 |
| breast | 100% | 2688.74 | 459 / 459 | 95% | 9.35 | 1062 / 1118 |
| pancreas | 100% | 13370.37 | 328 / 328 | 95% | 11.67 | 169 / 178 |
| thymus | 100% | 2825.60 | 653 / 653 | 95% | 12.49 | 572 / 605 |
| esophagus | 100% | 2578.86 | 1445 / 1445 | 95% | 9.51 | 173 / 183 |
| kidney | 100% | 1965.39 | 89 / 89 | 94% | 8.99 | 848 / 901 |
| liver | 99% | 2022.56 | 224 / 226 | 94% | 7.64 | 383 / 406 |
| lung | 100% | 2745.85 | 576 / 578 | 92% | 7.65 | 1063 / 1155 |
| skin | 100% | 3292.83 | 1807 / 1809 | 91% | 9.12 | 428 / 472 |
| uterus | 100% | 3851.39 | 170 / 170 | 86% | 7.33 | 397 / 459 |
| stomach | 99% | 1785.09 | 355 / 359 | 86% | 6.65 | 245 / 286 |
| intestine | 100% | 2288.02 | 963 / 966 | 81% | 5.45 | 429 / 527 |
| bladder | 100% | 2655.10 | 21 / 21 | 75% | 5.32 | 378 / 504 |
| adipose | 100% | 3323.75 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 1922.76 | 241 / 241 | 0% | 0 | 0 / 0 |
| blood vessel | 100% | 3851.59 | 1334 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 99% | 1578.06 | 795 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 98% | 7.83 | 78 / 80 |
| heart | 91% | 1466.71 | 787 / 861 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 87% | 4.68 | 39 / 45 |
| lymph node | 0% | 0 | 0 / 0 | 17% | 0.59 | 5 / 29 |
| peripheral blood | 5% | 35.93 | 43 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0050435 | Biological process | amyloid-beta metabolic process |
| GO_0140448 | Biological process | signaling receptor ligand precursor processing |
| GO_0010288 | Biological process | response to lead ion |
| GO_0016485 | Biological process | protein processing |
| GO_0050966 | Biological process | detection of mechanical stimulus involved in sensory perception of pain |
| GO_0071287 | Biological process | cellular response to manganese ion |
| GO_0043525 | Biological process | positive regulation of neuron apoptotic process |
| GO_0034205 | Biological process | amyloid-beta formation |
| GO_1990000 | Biological process | amyloid fibril formation |
| GO_0071280 | Biological process | cellular response to copper ion |
| GO_0006508 | Biological process | proteolysis |
| GO_0099171 | Biological process | presynaptic modulation of chemical synaptic transmission |
| GO_0060134 | Biological process | prepulse inhibition |
| GO_0042987 | Biological process | amyloid precursor protein catabolic process |
| GO_1904646 | Biological process | cellular response to amyloid-beta |
| GO_0006509 | Biological process | membrane protein ectodomain proteolysis |
| GO_0070931 | Cellular component | Golgi-associated vesicle lumen |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0045121 | Cellular component | membrane raft |
| GO_0016020 | Cellular component | membrane |
| GO_0055037 | Cellular component | recycling endosome |
| GO_0005769 | Cellular component | early endosome |
| GO_0005764 | Cellular component | lysosome |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0098686 | Cellular component | hippocampal mossy fiber to CA3 synapse |
| GO_0030425 | Cellular component | dendrite |
| GO_0005802 | Cellular component | trans-Golgi network |
| GO_0009986 | Cellular component | cell surface |
| GO_0005788 | Cellular component | endoplasmic reticulum lumen |
| GO_0008021 | Cellular component | synaptic vesicle |
| GO_0005770 | Cellular component | late endosome |
| GO_0005771 | Cellular component | multivesicular body |
| GO_0010008 | Cellular component | endosome membrane |
| GO_0030424 | Cellular component | axon |
| GO_0005768 | Cellular component | endosome |
| GO_0019899 | Molecular function | enzyme binding |
| GO_0008233 | Molecular function | peptidase activity |
| GO_0004175 | Molecular function | endopeptidase activity |
| GO_0001540 | Molecular function | amyloid-beta binding |
| GO_0120283 | Molecular function | protein serine/threonine kinase binding |
| GO_0004190 | Molecular function | aspartic-type endopeptidase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0008798 | Molecular function | beta-aspartyl-peptidase activity |
| Gene name | BACE1 |
| Protein name | BACE1 Beta-secretase 1 (EC 3.4.23.46) (Aspartyl protease 2) (ASP2) (Asp 2) (Beta-site amyloid precursor protein cleaving enzyme 1) (Beta-site APP cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Beta-secretase 1 (Beta-site APP-cleaving enzyme 1, isoform CRA_e) Beta-secretase 1 (EC 3.4.23.46) (Beta-site amyloid precursor protein cleaving enzyme 1) (Memapsin-2) (Membrane-associated aspartic protease 2) Beta-site APP-cleaving enzyme 1, isoform CRA_f (cDNA FLJ54693, highly similar to Beta-secretase 1) Beta-secretase 1 (Beta-site APP cleaving enzyme isoform I-127) Beta-secretase 1 |
| Synonyms | hCG_37942 BACE KIAA1149 |
| Description | FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves at the N-terminus of the A-beta peptide sequence, between residues 671 and 672 of APP, leads to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase . Cleaves CHL1 (By similarity). . |
| Accessions | B7Z3Z4 ENST00000428381.6 [P56817-4] ENST00000510630.5 [P56817-6] ENST00000392937.10 [P56817-5] ENST00000680681.1 Q76KP0 ENST00000510915.6 ENST00000680971.1 P56817 A0A7P0TAB4 E9PJG7 ENST00000528053.5 Q8IYC8 ENST00000514464.2 ENST00000445823.6 [P56817-3] Q6YBQ9 ENST00000313005.11 [P56817-1] A0A7P0T924 ENST00000513780.5 [P56817-2] U3KPS1 |
