Name | Number of supported studies | Average coverage | |
---|---|---|---|
natural killer cell | 12 studies | 20% ± 4% | |
B cell | 6 studies | 21% ± 7% | |
CD16-positive, CD56-dim natural killer cell, human | 5 studies | 18% ± 3% | |
CD8-positive, alpha-beta T cell | 5 studies | 22% ± 3% | |
fibroblast | 5 studies | 24% ± 7% | |
epithelial cell | 5 studies | 39% ± 16% | |
CD4-positive, alpha-beta T cell | 4 studies | 17% ± 2% | |
conventional dendritic cell | 4 studies | 32% ± 14% | |
non-classical monocyte | 4 studies | 27% ± 10% | |
myofibroblast cell | 4 studies | 17% ± 3% | |
pericyte | 4 studies | 23% ± 7% | |
endothelial cell | 4 studies | 31% ± 10% | |
ciliated cell | 4 studies | 24% ± 6% | |
goblet cell | 4 studies | 24% ± 6% | |
plasmacytoid dendritic cell | 4 studies | 20% ± 3% | |
classical monocyte | 3 studies | 31% ± 8% | |
hematopoietic precursor cell | 3 studies | 28% ± 7% | |
smooth muscle cell | 3 studies | 24% ± 8% | |
regulatory T cell | 3 studies | 19% ± 2% | |
erythroblast | 3 studies | 35% ± 22% | |
enteroendocrine cell | 3 studies | 26% ± 11% | |
intestinal crypt stem cell | 3 studies | 19% ± 2% | |
neuron | 3 studies | 29% ± 18% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 3894.73 | 2642 / 2642 | 100% | 32.99 | 705 / 705 |
esophagus | 100% | 3178.96 | 1445 / 1445 | 100% | 16.33 | 183 / 183 |
liver | 100% | 1923.31 | 226 / 226 | 100% | 24.74 | 406 / 406 |
lung | 100% | 2858.02 | 578 / 578 | 100% | 22.75 | 1155 / 1155 |
ovary | 100% | 2769.99 | 180 / 180 | 100% | 30.39 | 430 / 430 |
pancreas | 100% | 1780.67 | 328 / 328 | 100% | 27.08 | 178 / 178 |
skin | 100% | 3159.80 | 1809 / 1809 | 100% | 27.55 | 472 / 472 |
stomach | 100% | 2725.20 | 359 / 359 | 100% | 21.01 | 286 / 286 |
thymus | 100% | 2659.60 | 653 / 653 | 100% | 24.01 | 605 / 605 |
uterus | 100% | 3283.64 | 170 / 170 | 100% | 40.85 | 459 / 459 |
kidney | 100% | 3066.53 | 89 / 89 | 100% | 20.85 | 900 / 901 |
intestine | 100% | 3551.23 | 966 / 966 | 100% | 26.39 | 526 / 527 |
bladder | 100% | 3156.33 | 21 / 21 | 100% | 33.13 | 503 / 504 |
adrenal gland | 100% | 3388.27 | 258 / 258 | 100% | 28.68 | 229 / 230 |
prostate | 100% | 3316.71 | 245 / 245 | 99% | 29.31 | 499 / 502 |
breast | 100% | 3101.16 | 459 / 459 | 99% | 27.75 | 1111 / 1118 |
adipose | 100% | 2925.89 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 22.82 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 58.73 | 29 / 29 |
muscle | 100% | 4218.85 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 3922.75 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 32.63 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 33.70 | 1 / 1 |
blood vessel | 100% | 3185.58 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 3286.04 | 928 / 929 | 0% | 0 | 0 / 0 |
heart | 99% | 2755.16 | 851 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0007095 | Biological process | mitotic G2 DNA damage checkpoint signaling |
GO_0006282 | Biological process | regulation of DNA repair |
GO_0044818 | Biological process | mitotic G2/M transition checkpoint |
GO_0051301 | Biological process | cell division |
GO_0071425 | Biological process | hematopoietic stem cell proliferation |
GO_0010212 | Biological process | response to ionizing radiation |
GO_0045739 | Biological process | positive regulation of DNA repair |
GO_0140861 | Biological process | DNA repair-dependent chromatin remodeling |
GO_0006302 | Biological process | double-strand break repair |
GO_0070552 | Cellular component | BRISC complex |
GO_0070531 | Cellular component | BRCA1-A complex |
GO_0016604 | Cellular component | nuclear body |
GO_0005654 | Cellular component | nucleoplasm |
GO_0005829 | Cellular component | cytosol |
GO_0005737 | Cellular component | cytoplasm |
GO_0005634 | Cellular component | nucleus |
GO_0042802 | Molecular function | identical protein binding |
GO_0005515 | Molecular function | protein binding |
Gene name | BABAM1 |
Protein name | BRISC and BRCA1 A complex member 1 BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex) |
Synonyms | C19orf62 NBA1 MERIT40 HSPC142 |
Description | FUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates . In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . . |
Accessions | ENST00000601171.5 ENST00000596335.5 M0R0I0 ENST00000599474.5 M0QXG9 M0QZ44 ENST00000359435.8 [Q9NWV8-1] ENST00000601043.5 [Q9NWV8-1] M0R3F4 ENST00000598567.1 M0QYV1 ENST00000599057.5 ENST00000594247.5 M0R2I2 ENST00000598188.6 [Q9NWV8-1] ENST00000601232.1 M0R193 ENST00000447614.6 ENST00000602066.5 Q9NWV8 ENST00000596542.1 ENST00000595632.5 J3KQS6 M0R3H9 ENST00000601938.5 M0R2K3 M0R2A4 ENST00000601436.5 |