BABAM1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007095Biological processmitotic G2 DNA damage checkpoint signaling
GO_0006282Biological processregulation of DNA repair
GO_0044818Biological processmitotic G2/M transition checkpoint
GO_0051301Biological processcell division
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0010212Biological processresponse to ionizing radiation
GO_0045739Biological processpositive regulation of DNA repair
GO_0140861Biological processDNA repair-dependent chromatin remodeling
GO_0006302Biological processdouble-strand break repair
GO_0070552Cellular componentBRISC complex
GO_0070531Cellular componentBRCA1-A complex
GO_0016604Cellular componentnuclear body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameBABAM1
Protein nameBRISC and BRCA1 A complex member 1
BRISC and BRCA1-A complex member 1 (Mediator of RAP80 interactions and targeting subunit of 40 kDa) (New component of the BRCA1-A complex)
SynonymsC19orf62
NBA1
MERIT40
HSPC142
DescriptionFUNCTION: Component of the BRCA1-A complex, a complex that specifically recognizes 'Lys-63'-linked ubiquitinated histones H2A and H2AX at DNA lesions sites, leading to target the BRCA1-BARD1 heterodimer to sites of DNA damage at double-strand breaks (DSBs). The BRCA1-A complex also possesses deubiquitinase activity that specifically removes 'Lys-63'-linked ubiquitin on histones H2A and H2AX. In the BRCA1-A complex, it is required for the complex integrity and its localization at DSBs. Component of the BRISC complex, a multiprotein complex that specifically cleaves 'Lys-63'-linked ubiquitin in various substrates . In these 2 complexes, it is probably required to maintain the stability of BABAM2 and help the 'Lys-63'-linked deubiquitinase activity mediated by BRCC3/BRCC36 component. The BRISC complex is required for normal mitotic spindle assembly and microtubule attachment to kinetochores via its role in deubiquitinating NUMA1 . Plays a role in interferon signaling via its role in the deubiquitination of the interferon receptor IFNAR1; deubiquitination increases IFNAR1 activity by enhancing its stability and cell surface expression . Down-regulates the response to bacterial lipopolysaccharide (LPS) via its role in IFNAR1 deubiquitination . .

AccessionsENST00000601171.5
ENST00000596335.5
M0R0I0
ENST00000599474.5
M0QXG9
M0QZ44
ENST00000359435.8 [Q9NWV8-1]
ENST00000601043.5 [Q9NWV8-1]
M0R3F4
ENST00000598567.1
M0QYV1
ENST00000599057.5
ENST00000594247.5
M0R2I2
ENST00000598188.6 [Q9NWV8-1]
ENST00000601232.1
M0R193
ENST00000447614.6
ENST00000602066.5
Q9NWV8
ENST00000596542.1
ENST00000595632.5
J3KQS6
M0R3H9
ENST00000601938.5
M0R2K3
M0R2A4
ENST00000601436.5