B3GNT7 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of B3GNT7 at tissue level.

III. Associated gene sets

GO_0016266Biological processO-glycan processing
GO_0030311Biological processpoly-N-acetyllactosamine biosynthetic process
GO_0006493Biological processprotein O-linked glycosylation
GO_0018146Biological processkeratan sulfate biosynthetic process
GO_0000139Cellular componentGolgi membrane
GO_0008375Molecular functionacetylglucosaminyltransferase activity
GO_0008194Molecular functionUDP-glycosyltransferase activity
GO_0008499Molecular functionUDP-galactose:beta-N-acetylglucosamine beta-1,3-galactosyltransferase activity
GO_0005515Molecular functionprotein binding
GO_0008532Molecular functionN-acetyllactosaminide beta-1,3-N-acetylglucosaminyltransferase activity

IV. Literature review

[source]
Gene nameB3GNT7
Protein nameUDP-GlcNAc:betaGal beta-1,3-N-acetylglucosaminyltransferase 7 (BGnT-7) (Beta-1,3-Gn-T7) (Beta-1,3-N-acetylglucosaminyltransferase 7) (Beta3Gn-T7) (EC 2.4.1.-)
Synonyms
DescriptionFUNCTION: N-acetyl glucosamine (GlcNAc) transferase that catalyzes the transfer of GlcNAc via a beta1->3 linkage from UDP-GlcNAc to the non-reducing terminal galactose (Gal) in the linearly growing chain of N- and O-linked keratan sulfate proteoglycans. Cooperates with B4GALT4 galactosyltransferase and CHST6 and CHST1 sulfotransferases to construct and elongate mono- and disulfated disaccharide units [->3Galbeta1->4(6-sulfoGlcNAcbeta)1->] and [->3(6-sulfoGalbeta)1->4(6-sulfoGlcNAcbeta)1->] within keratan sulfate polymer . Involved in biosynthesis of N-linked keratan sulfate proteoglycans in cornea, with an impact on proteoglycan fibril organization and corneal transparency (By similarity). May play a role in the maintenance of tissue architecture by suppressing cellular motility and invasion (By similarity). .

AccessionsENST00000287590.6
Q8NFL0