ATP9A report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006890Biological processretrograde vesicle-mediated transport, Golgi to endoplasmic reticulum
GO_0006897Biological processendocytosis
GO_0048812Biological processneuron projection morphogenesis
GO_0045332Biological processphospholipid translocation
GO_1903542Biological processnegative regulation of exosomal secretion
GO_2001135Biological processregulation of endocytic recycling
GO_1905279Biological processregulation of retrograde transport, endosome to Golgi
GO_0031902Cellular componentlate endosome membrane
GO_0005886Cellular componentplasma membrane
GO_0048471Cellular componentperinuclear region of cytoplasm
GO_0055037Cellular componentrecycling endosome
GO_0005769Cellular componentearly endosome
GO_0031901Cellular componentearly endosome membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005802Cellular componenttrans-Golgi network
GO_0032588Cellular componenttrans-Golgi network membrane
GO_0005770Cellular componentlate endosome
GO_0005768Cellular componentendosome
GO_0140326Molecular functionATPase-coupled intramembrane lipid transporter activity
GO_0000287Molecular functionmagnesium ion binding
GO_0002020Molecular functionprotease binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameATP9A
Protein nameATP9A protein
Probable phospholipid-transporting ATPase IIA (EC 7.6.2.1) (ATPase class II type 9A)
Phospholipid-transporting ATPase (EC 7.6.2.1)
SynonymsKIAA0611
ATPIIA
DescriptionFUNCTION: Plays a role in regulating membrane trafficking of cargo proteins, namely endosome to plasma membrane recycling, probably acting through RAB5 and RAB11 activation . Also involved in endosome to trans-Golgi network retrograde transport . In complex with MON2 and DOP1B, regulates SNX3 retromer-mediated endosomal sorting of WLS, a transporter of Wnt morphogens in developing tissues. Participates in the formation of endosomal carriers that direct WLS trafficking back to Golgi, away from lysosomal degradation . Appears to be implicated in intercellular communication by negatively regulating the release of exosomes . The flippase activity towards membrane lipids and its role in membrane asymmetry remains to be proved . Required for the maintenance of neurite morphology and synaptic transmission (By similarity). .

AccessionsENST00000311637.9
O75110
Q96B35
ENST00000338821.6 [O75110-1]
A0A0A0MR22
Q2NLD0