ATP6V1B1 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP6V1B1 at tissue level.

III. Associated gene sets

GO_0055074Biological processcalcium ion homeostasis
GO_0007605Biological processsensory perception of sound
GO_0010468Biological processregulation of gene expression
GO_0055064Biological processchloride ion homeostasis
GO_0003091Biological processrenal water homeostasis
GO_0035812Biological processrenal sodium excretion
GO_0046034Biological processATP metabolic process
GO_0006885Biological processregulation of pH
GO_0055075Biological processpotassium ion homeostasis
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0097254Biological processrenal tubular secretion
GO_0042048Biological processolfactory behavior
GO_0045851Biological processpH reduction
GO_0003096Biological processrenal sodium ion transport
GO_0070072Biological processvacuolar proton-transporting V-type ATPase complex assembly
GO_0006693Biological processprostaglandin metabolic process
GO_0030534Biological processadult behavior
GO_0042472Biological processinner ear morphogenesis
GO_0007035Biological processvacuolar acidification
GO_0001503Biological processossification
GO_0016241Biological processregulation of macroautophagy
GO_1902600Biological processproton transmembrane transport
GO_0005902Cellular componentmicrovillus
GO_0016324Cellular componentapical plasma membrane
GO_0070062Cellular componentextracellular exosome
GO_0000221Cellular componentvacuolar proton-transporting V-type ATPase, V1 domain
GO_0005829Cellular componentcytosol
GO_0098850Cellular componentextrinsic component of synaptic vesicle membrane
GO_0016328Cellular componentlateral plasma membrane
GO_0005737Cellular componentcytoplasm
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0016323Cellular componentbasolateral plasma membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0015078Molecular functionproton transmembrane transporter activity
GO_0044877Molecular functionprotein-containing complex binding
GO_0005524Molecular functionATP binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V1B1
Protein nameTruncated ATPase V-type subunit B1
ATPase H+ transporting V1 subunit B1
ATPase V-type subunit B1
Vacuolar proton pump subunit B (V-ATPase subunit B) (Vacuolar proton pump subunit B)
V-type proton ATPase subunit B, kidney isoform (V-ATPase subunit B 1) (Endomembrane proton pump 58 kDa subunit) (Vacuolar proton pump subunit B 1)
SynonymsVPP3
ATP6B1
VATB
DescriptionFUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons . V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment . Essential for the proper assembly and activity of V-ATPase . In renal intercalated cells, mediates secretion of protons (H+) into the urine thereby ensuring correct urinary acidification . Required for optimal olfactory function by mediating the acidification of the nasal olfactory epithelium (By similarity). .

FUNCTION: Non-catalytic subunit of the V1 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment. .

AccessionsC9JL73
ENST00000234396.10
C9JZ02
V5NR16
ENST00000433895.2
ENST00000454446.6
C9JNS9
P15313
A0A097NUG1
ENST00000412314.5