ATP6V0D2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATP6V0D2 at tissue level.

III. Associated gene sets

GO_0007035Biological processvacuolar acidification
GO_1902600Biological processproton transmembrane transport
GO_0016241Biological processregulation of macroautophagy
GO_0007034Biological processvacuolar transport
GO_0016324Cellular componentapical plasma membrane
GO_0033179Cellular componentproton-transporting V-type ATPase, V0 domain
GO_0010008Cellular componentendosome membrane
GO_0070062Cellular componentextracellular exosome
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0033181Cellular componentplasma membrane proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V0D2
Protein nameATPase H+ transporting V0 subunit d2
V-type proton ATPase subunit d 2 (V-ATPase subunit d 2) (Vacuolar proton pump subunit d 2)
Synonyms
DescriptionFUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons. V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). May play a role in coupling of proton transport and ATP hydrolysis (By similarity). Regulator of osteoclast fusion and bone formation (By similarity). .

AccessionsQ8N8Y2
ENST00000285393.4
E5RIR3
E5RHJ7
ENST00000523635.1
ENST00000521564.1