ATP6V0A4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007605Biological processsensory perception of sound
GO_0006885Biological processregulation of pH
GO_0051452Biological processintracellular pH reduction
GO_0097401Biological processsynaptic vesicle lumen acidification
GO_0097254Biological processrenal tubular secretion
GO_0007035Biological processvacuolar acidification
GO_0001503Biological processossification
GO_1902600Biological processproton transmembrane transport
GO_0031526Cellular componentbrush border membrane
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0030672Cellular componentsynaptic vesicle membrane
GO_0070062Cellular componentextracellular exosome
GO_0033176Cellular componentproton-transporting V-type ATPase complex
GO_0030670Cellular componentphagocytic vesicle membrane
GO_0000220Cellular componentvacuolar proton-transporting V-type ATPase, V0 domain
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0016471Cellular componentvacuolar proton-transporting V-type ATPase complex
GO_0005765Cellular componentlysosomal membrane
GO_0045177Cellular componentapical part of cell
GO_0016323Cellular componentbasolateral plasma membrane
GO_0046961Molecular functionproton-transporting ATPase activity, rotational mechanism
GO_0051117Molecular functionATPase binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATP6V0A4
Protein nameV-type proton ATPase subunit a
V-type proton ATPase 116 kDa subunit a 4 (V-ATPase 116 kDa isoform a 4) (Vacuolar proton translocating ATPase 116 kDa subunit a isoform 4) (Vacuolar proton translocating ATPase 116 kDa subunit a kidney isoform)
SynonymsATP6N2
ATP6N1B
DescriptionFUNCTION: Subunit of the V0 complex of vacuolar(H+)-ATPase (V-ATPase), a multisubunit enzyme composed of a peripheral complex (V1) that hydrolyzes ATP and a membrane integral complex (V0) that translocates protons (By similarity). V-ATPase is responsible for acidifying and maintaining the pH of intracellular compartments and in some cell types, is targeted to the plasma membrane, where it is responsible for acidifying the extracellular environment (By similarity). Involved in normal vectorial acid transport into the urine by the kidney . .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

FUNCTION: Essential component of the vacuolar proton pump (V-ATPase), a multimeric enzyme that catalyzes the translocation of protons across the membranes. Required for assembly and activity of the V-ATPase. .

AccessionsA0A2R8Y7G6
ENST00000645515.1
ENST00000310018.7
A0A2R8YE46
ENST00000483139.1
ENST00000353492.4
A0A2R8Y6X9
A0A2R8YGN5
Q9HBG4
ENST00000478480.2
ENST00000393054.5
ENST00000647427.1
ENST00000644341.1