Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 23 studies | 67% ± 18% | |
| oligodendrocyte precursor cell | 12 studies | 35% ± 16% | |
| smooth muscle cell | 10 studies | 34% ± 23% | |
| adipocyte | 9 studies | 33% ± 12% | |
| pericyte | 8 studies | 44% ± 25% | |
| endothelial cell | 7 studies | 43% ± 15% | |
| cardiac muscle cell | 4 studies | 39% ± 6% | |
| glial cell | 3 studies | 30% ± 11% | |
| muscle cell | 3 studies | 38% ± 17% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 68183.12 | 2599 / 2642 | 99% | 589.63 | 701 / 705 |
| prostate | 26% | 3395.43 | 63 / 245 | 82% | 16.86 | 412 / 502 |
| muscle | 100% | 116975.16 | 803 / 803 | 0% | 0 | 0 / 0 |
| heart | 76% | 18813.00 | 658 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 76% | 14326.37 | 1019 / 1335 | 0% | 0 | 0 / 0 |
| esophagus | 51% | 10058.38 | 739 / 1445 | 16% | 2.33 | 29 / 183 |
| intestine | 52% | 8213.03 | 503 / 966 | 8% | 0.91 | 40 / 527 |
| breast | 33% | 5008.83 | 152 / 459 | 17% | 2.27 | 187 / 1118 |
| adipose | 49% | 7027.30 | 591 / 1204 | 0% | 0 | 0 / 0 |
| bladder | 38% | 5868.19 | 8 / 21 | 10% | 2.40 | 48 / 504 |
| adrenal gland | 0% | 125.89 | 1 / 258 | 37% | 3.42 | 86 / 230 |
| stomach | 19% | 2609.90 | 68 / 359 | 14% | 1.95 | 39 / 286 |
| kidney | 0% | 0 | 0 / 89 | 27% | 2.13 | 247 / 901 |
| ovary | 12% | 1372.76 | 21 / 180 | 13% | 2.86 | 55 / 430 |
| thymus | 1% | 135.79 | 7 / 653 | 18% | 1.65 | 111 / 605 |
| pancreas | 0% | 0 | 0 / 328 | 19% | 2.23 | 33 / 178 |
| uterus | 3% | 412.53 | 5 / 170 | 15% | 5.25 | 67 / 459 |
| eye | 0% | 0 | 0 / 0 | 15% | 2.18 | 12 / 80 |
| lung | 1% | 83.44 | 5 / 578 | 10% | 1.22 | 112 / 1155 |
| tonsil | 0% | 0 | 0 / 0 | 9% | 1.30 | 4 / 45 |
| skin | 0% | 94.76 | 4 / 1809 | 8% | 3.52 | 38 / 472 |
| liver | 0% | 0 | 0 / 226 | 8% | 1.43 | 31 / 406 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| peripheral blood | 0% | 0 | 0 / 929 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spleen | 0% | 0 | 0 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071260 | Biological process | cellular response to mechanical stimulus |
| GO_0002026 | Biological process | regulation of the force of heart contraction |
| GO_0046034 | Biological process | ATP metabolic process |
| GO_0019852 | Biological process | L-ascorbic acid metabolic process |
| GO_0060048 | Biological process | cardiac muscle contraction |
| GO_0071805 | Biological process | potassium ion transmembrane transport |
| GO_0045822 | Biological process | negative regulation of heart contraction |
| GO_1903280 | Biological process | negative regulation of calcium:sodium antiporter activity |
| GO_0035094 | Biological process | response to nicotine |
| GO_0001662 | Biological process | behavioral fear response |
| GO_0036376 | Biological process | sodium ion export across plasma membrane |
| GO_1990573 | Biological process | potassium ion import across plasma membrane |
| GO_0010996 | Biological process | response to auditory stimulus |
| GO_0035864 | Biological process | response to potassium ion |
| GO_0008217 | Biological process | regulation of blood pressure |
| GO_0071383 | Biological process | cellular response to steroid hormone stimulus |
| GO_0051966 | Biological process | regulation of synaptic transmission, glutamatergic |
| GO_0006883 | Biological process | intracellular sodium ion homeostasis |
| GO_0008542 | Biological process | visual learning |
| GO_0010881 | Biological process | regulation of cardiac muscle contraction by regulation of the release of sequestered calcium ion |
| GO_0045988 | Biological process | negative regulation of striated muscle contraction |
| GO_0006814 | Biological process | sodium ion transport |
| GO_0010248 | Biological process | establishment or maintenance of transmembrane electrochemical gradient |
| GO_0021989 | Biological process | olfactory cortex development |
| GO_0006942 | Biological process | regulation of striated muscle contraction |
| GO_0086004 | Biological process | regulation of cardiac muscle cell contraction |
| GO_0051946 | Biological process | regulation of glutamate uptake involved in transmission of nerve impulse |
| GO_0086064 | Biological process | cell communication by electrical coupling involved in cardiac conduction |
| GO_1903416 | Biological process | response to glycoside |
| GO_0035725 | Biological process | sodium ion transmembrane transport |
| GO_0019227 | Biological process | neuronal action potential propagation |
| GO_0086012 | Biological process | membrane depolarization during cardiac muscle cell action potential |
| GO_0006813 | Biological process | potassium ion transport |
| GO_0002087 | Biological process | regulation of respiratory gaseous exchange by nervous system process |
| GO_0021764 | Biological process | amygdala development |
| GO_0019229 | Biological process | regulation of vasoconstriction |
| GO_0006937 | Biological process | regulation of muscle contraction |
| GO_0150104 | Biological process | transport across blood-brain barrier |
| GO_0008344 | Biological process | adult locomotory behavior |
| GO_0006940 | Biological process | regulation of smooth muscle contraction |
| GO_0040011 | Biological process | locomotion |
| GO_0055119 | Biological process | relaxation of cardiac muscle |
| GO_0001504 | Biological process | neurotransmitter uptake |
| GO_1903170 | Biological process | negative regulation of calcium ion transmembrane transport |
| GO_0098655 | Biological process | monoatomic cation transmembrane transport |
| GO_0045823 | Biological process | positive regulation of heart contraction |
| GO_0035641 | Biological process | locomotory exploration behavior |
| GO_0030007 | Biological process | intracellular potassium ion homeostasis |
| GO_0086009 | Biological process | membrane repolarization |
| GO_1902600 | Biological process | proton transmembrane transport |
| GO_0051481 | Biological process | negative regulation of cytosolic calcium ion concentration |
| GO_1903561 | Cellular component | extracellular vesicle |
| GO_0043025 | Cellular component | neuronal cell body |
| GO_0009986 | Cellular component | cell surface |
| GO_0005768 | Cellular component | endosome |
| GO_0014704 | Cellular component | intercalated disc |
| GO_0005890 | Cellular component | sodium:potassium-exchanging ATPase complex |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0016020 | Cellular component | membrane |
| GO_0030315 | Cellular component | T-tubule |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005901 | Cellular component | caveola |
| GO_0043197 | Cellular component | dendritic spine |
| GO_0042995 | Cellular component | cell projection |
| GO_0031090 | Cellular component | organelle membrane |
| GO_0019829 | Molecular function | ATPase-coupled monoatomic cation transmembrane transporter activity |
| GO_0005391 | Molecular function | P-type sodium:potassium-exchanging transporter activity |
| GO_0005524 | Molecular function | ATP binding |
| GO_0046982 | Molecular function | protein heterodimerization activity |
| GO_0031402 | Molecular function | sodium ion binding |
| GO_0005496 | Molecular function | steroid binding |
| GO_0051087 | Molecular function | protein-folding chaperone binding |
| GO_0016791 | Molecular function | phosphatase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_1990239 | Molecular function | steroid hormone binding |
| GO_0030955 | Molecular function | potassium ion binding |
| GO_0016887 | Molecular function | ATP hydrolysis activity |
| Gene name | ATP1A2 |
| Protein name | Sodium/potassium-transporting ATPase subunit alpha-2 (Sodium pump subunit alpha-2) Sodium/potassium-transporting ATPase subunit alpha Sodium/potassium-transporting ATPase subunit alpha-2 (Na(+)/K(+) ATPase alpha-2 subunit) (EC 7.2.2.13) (Sodium pump subunit alpha-2) Na+/K+ transporting ATPase alpha 2 polypeptide |
| Synonyms | KIAA0778 |
| Description | FUNCTION: This is the catalytic component of the active enzyme, which catalyzes the hydrolysis of ATP coupled with the exchange of sodium and potassium ions across the plasma membrane. This action creates the electrochemical gradient of sodium and potassium, providing the energy for active transport of various nutrients. . |
| Accessions | ENST00000447527.1 P50993 ENST00000392233.7 A0A0S2Z3W6 ENST00000361216.8 H0Y7C1 Q58I22 A0A0S2Z3D3 B1AKY9 |
