ATOH7 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ATOH7 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ATOH7 at tissue level.

III. Associated gene sets

GO_1902336Biological processpositive regulation of retinal ganglion cell axon guidance
GO_0010996Biological processresponse to auditory stimulus
GO_0061564Biological processaxon development
GO_0048663Biological processneuron fate commitment
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0007623Biological processcircadian rhythm
GO_0021554Biological processoptic nerve development
GO_0043153Biological processentrainment of circadian clock by photoperiod
GO_0007423Biological processsensory organ development
GO_0003407Biological processneural retina development
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0043204Cellular componentperikaryon
GO_0030424Cellular componentaxon
GO_0000785Cellular componentchromatin
GO_0005634Cellular componentnucleus
GO_0000981Molecular functionDNA-binding transcription factor activity, RNA polymerase II-specific
GO_0000976Molecular functiontranscription cis-regulatory region binding
GO_1990837Molecular functionsequence-specific double-stranded DNA binding
GO_0003700Molecular functionDNA-binding transcription factor activity
GO_0070888Molecular functionE-box binding
GO_0046983Molecular functionprotein dimerization activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameATOH7
Protein nameTranscription factor ATOH7 (Atonal bHLH transcription factor 7) (Class A basic helix-loop-helix protein 13) (bHLHa13) (Protein atonal homolog 7)
HCG1795924 (Protein atonal homolog 7)
SynonymshCG_1795924
BHLHA13
ATH5
DescriptionFUNCTION: Transcription factor that binds to DNA at the consensus sequence 5'-CAG[GC]TG-3' . Dimerization with TCF3 isoform E47 may be required in certain situations . Binds to gene promoters and enhancer elements, and thereby regulates a transcriptional program of retinal ganglion cell (RGC) determinant genes (By similarity). Although the exact mechanism is not certain, retinal transcription regulation by ATOH7 has a role in RGC determination and survival, photoreceptor population development, targeting of RGC axons to the optic nerve and development of the retino-hypothalamic tract (By similarity). Binds to its own promoter and enhancer sequences, suggesting autoregulation of ATOH7 transcription (By similarity). Required for retinal circadian rhythm photoentrainment (By similarity). Plays a role in brainstem auditory signaling and binaural processing (By similarity). .

AccessionsENST00000373673.5
Q8N100
F1T0H4