Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| CD4-positive, alpha-beta T cell | 4 studies | 29% ± 6% | |
| CD8-positive, alpha-beta T cell | 4 studies | 26% ± 5% | |
| B cell | 3 studies | 21% ± 4% | |
| T cell | 3 studies | 21% ± 5% | |
| natural killer cell | 3 studies | 27% ± 9% |
Insufficient scRNA-seq data for expression of ASF1B at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| skin | 85% | 533.85 | 1535 / 1809 | 96% | 47.36 | 453 / 472 |
| lung | 76% | 207.92 | 440 / 578 | 90% | 48.31 | 1045 / 1155 |
| intestine | 55% | 343.16 | 530 / 966 | 98% | 75.93 | 518 / 527 |
| stomach | 54% | 233.01 | 194 / 359 | 97% | 66.95 | 277 / 286 |
| esophagus | 44% | 330.03 | 641 / 1445 | 98% | 58.92 | 180 / 183 |
| breast | 45% | 61.50 | 208 / 459 | 94% | 51.47 | 1050 / 1118 |
| ovary | 34% | 45.33 | 61 / 180 | 98% | 89.41 | 423 / 430 |
| bladder | 33% | 46.48 | 7 / 21 | 95% | 69.27 | 481 / 504 |
| uterus | 14% | 26.05 | 24 / 170 | 99% | 124.10 | 456 / 459 |
| adrenal gland | 74% | 118.06 | 191 / 258 | 27% | 13.51 | 63 / 230 |
| lymph node | 0% | 0 | 0 / 0 | 100% | 102.96 | 29 / 29 |
| spleen | 100% | 610.87 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 148.24 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 40.45 | 1 / 1 |
| peripheral blood | 99% | 1683.30 | 918 / 929 | 0% | 0 | 0 / 0 |
| pancreas | 15% | 17.91 | 48 / 328 | 80% | 24.68 | 143 / 178 |
| thymus | 27% | 35.63 | 178 / 653 | 54% | 24.54 | 327 / 605 |
| kidney | 37% | 88.48 | 33 / 89 | 31% | 6.90 | 277 / 901 |
| liver | 22% | 53.03 | 49 / 226 | 44% | 13.62 | 180 / 406 |
| prostate | 39% | 56.91 | 96 / 245 | 22% | 5.05 | 110 / 502 |
| brain | 2% | 2.84 | 41 / 2642 | 40% | 17.60 | 285 / 705 |
| adipose | 35% | 54.41 | 419 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 30% | 4.96 | 24 / 80 |
| blood vessel | 18% | 23.16 | 239 / 1335 | 0% | 0 | 0 / 0 |
| muscle | 10% | 11.49 | 81 / 803 | 0% | 0 | 0 / 0 |
| heart | 10% | 12.98 | 83 / 861 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0006335 | Biological process | DNA replication-dependent chromatin assembly |
| GO_0007283 | Biological process | spermatogenesis |
| GO_0030154 | Biological process | cell differentiation |
| GO_0001835 | Biological process | blastocyst hatching |
| GO_0006334 | Biological process | nucleosome assembly |
| GO_0032991 | Cellular component | protein-containing complex |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0000785 | Cellular component | chromatin |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0140713 | Molecular function | histone chaperone activity |
| GO_0042393 | Molecular function | histone binding |
| Gene name | ASF1B |
| Protein name | Anti-silencing function 1B histone chaperone Histone chaperone ASF1B (Anti-silencing function protein 1 homolog B) (hAsf1) (hAsf1b) (CCG1-interacting factor A-II) (CIA-II) (hCIA-II) |
| Synonyms | |
| Description | FUNCTION: Histone chaperone that facilitates histone deposition and histone exchange and removal during nucleosome assembly and disassembly . Cooperates with chromatin assembly factor 1 (CAF-1) to promote replication-dependent chromatin assembly . Also involved in the nuclear import of the histone H3-H4 dimer together with importin-4 (IPO4): specifically recognizes and binds newly synthesized histones with the monomethylation of H3 'Lys-9' (H3K9me1) and diacetylation at 'Lys-5' and 'Lys-12' of H4 (H4K5K12ac) marks in the cytosol . Does not participate in replication-independent nucleosome deposition which is mediated by ASF1A and HIRA . Required for gonad development . . |
| Accessions | ENST00000590835.5 ENST00000592798.5 ENST00000672225.1 ENST00000263382.8 K7EM93 ENST00000589468.1 ENST00000474890.1 Q9NVP2 K7ES22 K7ELW9 K7EIL9 |
