ARL6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0007601Biological processvisual perception
GO_0061512Biological processprotein localization to cilium
GO_0007368Biological processdetermination of left/right symmetry
GO_0006886Biological processintracellular protein transport
GO_0006612Biological processprotein targeting to membrane
GO_0032402Biological processmelanosome transport
GO_0016192Biological processvesicle-mediated transport
GO_0051258Biological processprotein polymerization
GO_0016055Biological processWnt signaling pathway
GO_0030117Cellular componentmembrane coat
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0070062Cellular componentextracellular exosome
GO_0005930Cellular componentaxoneme
GO_0005879Cellular componentaxonemal microtubule
GO_0005929Cellular componentcilium
GO_0015630Cellular componentmicrotubule cytoskeleton
GO_0005737Cellular componentcytoplasm
GO_0005543Molecular functionphospholipid binding
GO_0005525Molecular functionGTP binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding
GO_0003924Molecular functionGTPase activity

IV. Literature review

[source]
Gene nameARL6
Protein nameADP-ribosylation factor-like protein 6
ADP ribosylation factor like GTPase 6
ADP-ribosylation factor-like protein 6 (Bardet-Biedl syndrome 3 protein)
SynonymsBBS3
DescriptionFUNCTION: Involved in membrane protein trafficking at the base of the ciliary organelle. Mediates recruitment onto plasma membrane of the BBSome complex which would constitute a coat complex required for sorting of specific membrane proteins to the primary cilia . Together with BBS1, is necessary for correct trafficking of PKD1 to primary cilia (By similarity). Together with the BBSome complex and LTZL1, controls SMO ciliary trafficking and contributes to the sonic hedgehog (SHH) pathway regulation . May regulate cilia assembly and disassembly and subsequent ciliary signaling events such as the Wnt signaling cascade . Isoform 2 may be required for proper retinal function and organization (By similarity). .

AccessionsA0A0J9YXT0
ENST00000462412.2
C9IZ13
H7C5H6
ENST00000335979.6 [Q9H0F7-1]
ENST00000631834.1
ENST00000476753.1
ENST00000462412.3 [Q9H0F7-1]
ENST00000463745.6 [Q9H0F7-1]
Q9H0F7
ENST00000493990.5 [Q9H0F7-1]
ENST00000631834.2 [Q9H0F7-2]