ARG1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070965Biological processpositive regulation of neutrophil mediated killing of fungus
GO_0045087Biological processinnate immune response
GO_0042832Biological processdefense response to protozoan
GO_0060336Biological processnegative regulation of type II interferon-mediated signaling pathway
GO_0006527Biological processarginine catabolic process
GO_2000552Biological processnegative regulation of T-helper 2 cell cytokine production
GO_0002250Biological processadaptive immune response
GO_0019547Biological processarginine catabolic process to ornithine
GO_0000050Biological processurea cycle
GO_0046007Biological processnegative regulation of activated T cell proliferation
GO_0042130Biological processnegative regulation of T cell proliferation
GO_0035578Cellular componentazurophil granule lumen
GO_0005615Cellular componentextracellular space
GO_0005576Cellular componentextracellular region
GO_0035580Cellular componentspecific granule lumen
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0030145Molecular functionmanganese ion binding
GO_0004053Molecular functionarginase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARG1
Protein nameArginase 1
Arginase-1 (EC 3.5.3.1) (Liver-type arginase) (Type I arginase)
Arginase (EC 3.5.3.1)
Arginase-1 (Liver-type arginase) (Type I arginase)
Synonyms
DescriptionFUNCTION: Key element of the urea cycle converting L-arginine to urea and L-ornithine, which is further metabolized into metabolites proline and polyamides that drive collagen synthesis and bioenergetic pathways critical for cell proliferation, respectively; the urea cycle takes place primarily in the liver and, to a lesser extent, in the kidneys. .; FUNCTION: Functions in L-arginine homeostasis in nonhepatic tissues characterized by the competition between nitric oxide synthase (NOS) and arginase for the available intracellular substrate arginine. Arginine metabolism is a critical regulator of innate and adaptive immune responses. Involved in an antimicrobial effector pathway in polymorphonuclear granulocytes (PMN). Upon PMN cell death is liberated from the phagolysosome and depletes arginine in the microenvironment leading to suppressed T cell and natural killer (NK) cell proliferation and cytokine secretion . In group 2 innate lymphoid cells (ILC2s) promotes acute type 2 inflammation in the lung and is involved in optimal ILC2 proliferation but not survival (By similarity). In humans, the immunological role in the monocytic/macrophage/dendritic cell (DC) lineage is unsure. .

AccessionsENST00000368087.8 [P05089-1]
ENST00000673427.1
P05089
A0A5F9ZGY6
ENST00000672233.1
A0A5F9ZH78
ENST00000673234.1
ENST00000356962.2 [P05089-2]
A0A5F9ZGN6