ARC report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ARC at tissue level.

III. Associated gene sets

GO_0051260Biological processprotein homooligomerization
GO_0050804Biological processmodulation of chemical synaptic transmission
GO_0006897Biological processendocytosis
GO_0043278Biological processresponse to morphine
GO_1900271Biological processregulation of long-term synaptic potentiation
GO_0051028Biological processmRNA transport
GO_0007612Biological processlearning
GO_1900452Biological processregulation of long-term synaptic depression
GO_0007616Biological processlong-term memory
GO_0022604Biological processregulation of cell morphogenesis
GO_0007010Biological processcytoskeleton organization
GO_0110077Biological processvesicle-mediated intercellular transport
GO_0060291Biological processlong-term synaptic potentiation
GO_0045471Biological processresponse to ethanol
GO_0007492Biological processendoderm development
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_0061001Biological processregulation of dendritic spine morphogenesis
GO_0099149Biological processregulation of postsynaptic neurotransmitter receptor internalization
GO_0009952Biological processanterior/posterior pattern specification
GO_0016477Biological processcell migration
GO_0060997Biological processdendritic spine morphogenesis
GO_0098978Cellular componentglutamatergic synapse
GO_0098839Cellular componentpostsynaptic density membrane
GO_0001669Cellular componentacrosomal vesicle
GO_0005886Cellular componentplasma membrane
GO_0045121Cellular componentmembrane raft
GO_0043197Cellular componentdendritic spine
GO_0031901Cellular componentearly endosome membrane
GO_1903561Cellular componentextracellular vesicle
GO_0043025Cellular componentneuronal cell body
GO_0015629Cellular componentactin cytoskeleton
GO_0005829Cellular componentcytosol
GO_0005938Cellular componentcell cortex
GO_0170047Cellular componentvirus-like capsid
GO_0071598Cellular componentneuronal ribonucleoprotein granule
GO_0005737Cellular componentcytoplasm
GO_0030665Cellular componentclathrin-coated vesicle membrane
GO_0098845Cellular componentpostsynaptic endosome
GO_0003729Molecular functionmRNA binding
GO_0005198Molecular functionstructural molecule activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameARC
Protein nameActivity-regulated cytoskeleton-associated protein (hArc) (Activity-regulated gene 3.1 protein homolog) (ARC/ARG3.1) (Arg3.1)
SynonymsKIAA0278
DescriptionFUNCTION: Master regulator of synaptic plasticity that self-assembles into virion-like capsids that encapsulate RNAs and mediate intercellular RNA transfer in the nervous system. ARC protein is released from neurons in extracellular vesicles that mediate the transfer of ARC mRNA into new target cells, where ARC mRNA can undergo activity-dependent translation. ARC capsids are endocytosed and are able to transfer ARC mRNA into the cytoplasm of neurons. Acts as a key regulator of synaptic plasticity: required for protein synthesis-dependent forms of long-term potentiation (LTP) and depression (LTD) and for the formation of long-term memory. Regulates synaptic plasticity by promoting endocytosis of AMPA receptors (AMPARs) in response to synaptic activity: this endocytic pathway maintains levels of surface AMPARs in response to chronic changes in neuronal activity through synaptic scaling, thereby contributing to neuronal homeostasis. Acts as a postsynaptic mediator of activity-dependent synapse elimination in the developing cerebellum by mediating elimination of surplus climbing fiber synapses. Accumulates at weaker synapses, probably to prevent their undesired enhancement. This suggests that ARC-containing virion-like capsids may be required to eliminate synaptic material. Required to transduce experience into long-lasting changes in visual cortex plasticity and for long-term memory (By similarity). Involved in postsynaptic trafficking and processing of amyloid-beta A4 (APP) via interaction with PSEN1 (By similarity). In addition to its role in synapses, also involved in the regulation of the immune system: specifically expressed in skin-migratory dendritic cells and regulates fast dendritic cell migration, thereby regulating T-cell activation (By similarity). .

AccessionsENST00000356613.4
Q7LC44