APOBEC3H report

I. Expression across cell types

Insufficient scRNA-seq data for expression of APOBEC3H at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APOBEC3H at tissue level.

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0051607Biological processdefense response to virus
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0016554Biological processcytidine to uridine editing
GO_0044355Biological processclearance of foreign intracellular DNA
GO_0044828Biological processnegative regulation by host of viral genome replication
GO_0070383Biological processDNA cytosine deamination
GO_0009972Biological processcytidine deamination
GO_0045087Biological processinnate immune response
GO_0000932Cellular componentP-body
GO_0005654Cellular componentnucleoplasm
GO_0005829Cellular componentcytosol
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0004126Molecular functioncytidine deaminase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAPOBEC3H
Protein nameDNA dC->dU-editing enzyme APOBEC-3H (EC 3.5.4.38) (APOBEC-related protein 10) (ARP-10) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3H) (A3H)
single-stranded DNA cytosine deaminase (EC 3.5.4.38)
Synonyms
DescriptionFUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. The A3H-var/haplotype 2 exhibits antiviral activity against vif-deficient HIV-1. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. .

AccessionsA0A087WZI3
B7TQM4
Q6NTF7
ENST00000613677.4 [Q6NTF7-1]
B7TQM6
ENST00000348946.8 [Q6NTF7-2]
B7T0V0
ENST00000401756.5 [Q6NTF7-1]
B7TQM8
ENST00000613996.1
B7TQM9
ENST00000442487.8 [Q6NTF7-3]
B7TQM3
B7TQM7
ENST00000421988.6