APOBEC3F report

I. Expression across cell types

Insufficient scRNA-seq data for expression of APOBEC3F at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APOBEC3F at tissue level.

III. Associated gene sets

GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0045071Biological processnegative regulation of viral genome replication
GO_0016553Biological processbase conversion or substitution editing
GO_0045087Biological processinnate immune response
GO_0051607Biological processdefense response to virus
GO_0070383Biological processDNA cytosine deamination
GO_0009972Biological processcytidine deamination
GO_0010526Biological processretrotransposon silencing
GO_0016554Biological processcytidine to uridine editing
GO_0044355Biological processclearance of foreign intracellular DNA
GO_0048525Biological processnegative regulation of viral process
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0044029Biological processpositive regulation of gene expression via chromosomal CpG island demethylation
GO_0030895Cellular componentapolipoprotein B mRNA editing enzyme complex
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_1990904Cellular componentribonucleoprotein complex
GO_0005634Cellular componentnucleus
GO_0042802Molecular functionidentical protein binding
GO_0004126Molecular functioncytidine deaminase activity
GO_0008270Molecular functionzinc ion binding
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPOBEC3F
Protein nameApolipoprotein B mRNA editing enzyme cytidine deaminase
DNA dC->dU-editing enzyme APOBEC-3F (EC 3.5.4.38) (Apolipoprotein B mRNA-editing enzyme catalytic polypeptide-like 3F) (A3F)
Apolipoprotein B editing enzyme catalytic polypeptide-like 3F
Synonyms
DescriptionFUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. Exhibits antiviral activity against viruse such as HIV-1 or HIV-2 . After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA . The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity also against hepatitis B virus (HBV), equine infectious anemia virus (EIAV), xenotropic MuLV-related virus (XMRV) and simian foamy virus (SFV) and may inhibit the mobility of LTR and non-LTR retrotransposons. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. .

AccessionsENST00000308521.10 [Q8IUX4-1]
M4VR43
Q8IUX4
ENST00000381565.2 [Q8IUX4-3]
F2YHL7