APOBEC3B report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APOBEC3B at tissue level.

III. Associated gene sets

GO_0010526Biological processretrotransposon silencing
GO_0051607Biological processdefense response to virus
GO_0045869Biological processnegative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0016554Biological processcytidine to uridine editing
GO_0044355Biological processclearance of foreign intracellular DNA
GO_0070383Biological processDNA cytosine deamination
GO_0009972Biological processcytidine deamination
GO_0045087Biological processinnate immune response
GO_0000932Cellular componentP-body
GO_0005654Cellular componentnucleoplasm
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0004126Molecular functioncytidine deaminase activity
GO_0003723Molecular functionRNA binding

IV. Literature review

[source]
Gene nameAPOBEC3B
Protein nameApolipoprotein B mRNA editing enzyme catalytic subunit 3B
Apolipoprotein B mRNA editing enzyme catalytic polypeptide-like 3B (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3B, isoform CRA_c)
DNA dC->dU-editing enzyme APOBEC-3B (A3B) (EC 3.5.4.38) (Phorbolin-1-related protein) (Phorbolin-2/3)
SynonymshCG_1735023
DescriptionFUNCTION: DNA deaminase (cytidine deaminase) which acts as an inhibitor of retrovirus replication and retrotransposon mobility via deaminase-dependent and -independent mechanisms. After the penetration of retroviral nucleocapsids into target cells of infection and the initiation of reverse transcription, it can induce the conversion of cytosine to uracil in the minus-sense single-strand viral DNA, leading to G-to-A hypermutations in the subsequent plus-strand viral DNA. The resultant detrimental levels of mutations in the proviral genome, along with a deamination-independent mechanism that works prior to the proviral integration, together exert efficient antiretroviral effects in infected target cells. Selectively targets single-stranded DNA and does not deaminate double-stranded DNA or single- or double-stranded RNA. Exhibits antiviral activity against simian immunodeficiency virus (SIV), hepatitis B virus (HBV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. .

AccessionsQ9UH17
W0HJ78
ENST00000407298.7 [Q9UH17-3]
ENST00000333467.4 [Q9UH17-1]
ENST00000402182.7
B0QYD3
ENST00000335760.9 [Q9UH17-2]