Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| non-classical monocyte | 22 studies | 42% ± 12% | |
| classical monocyte | 21 studies | 31% ± 7% | |
| monocyte | 9 studies | 35% ± 14% | |
| neutrophil | 6 studies | 25% ± 4% | |
| intermediate monocyte | 5 studies | 39% ± 20% |
Insufficient scRNA-seq data for expression of APOBEC3A at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| lung | 100% | 911.44 | 576 / 578 | 70% | 6.41 | 807 / 1155 |
| esophagus | 34% | 219.22 | 486 / 1445 | 72% | 17.19 | 132 / 183 |
| spleen | 100% | 3245.54 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 98% | 57.77 | 44 / 45 |
| thymus | 66% | 74.50 | 433 / 653 | 29% | 0.78 | 177 / 605 |
| uterus | 13% | 27.93 | 22 / 170 | 73% | 24.86 | 336 / 459 |
| peripheral blood | 82% | 12071.23 | 758 / 929 | 0% | 0 | 0 / 0 |
| bladder | 19% | 31.86 | 4 / 21 | 59% | 7.19 | 296 / 504 |
| breast | 36% | 44.48 | 165 / 459 | 39% | 1.92 | 440 / 1118 |
| stomach | 25% | 54.25 | 88 / 359 | 46% | 1.22 | 131 / 286 |
| intestine | 29% | 48.28 | 283 / 966 | 34% | 1.51 | 179 / 527 |
| liver | 55% | 65.03 | 124 / 226 | 6% | 0.19 | 23 / 406 |
| adipose | 60% | 185.89 | 719 / 1204 | 0% | 0 | 0 / 0 |
| kidney | 24% | 26.09 | 21 / 89 | 36% | 0.82 | 323 / 901 |
| ovary | 5% | 5.22 | 9 / 180 | 54% | 1.92 | 234 / 430 |
| lymph node | 0% | 0 | 0 / 0 | 55% | 8.68 | 16 / 29 |
| pancreas | 7% | 5.60 | 23 / 328 | 31% | 1.09 | 56 / 178 |
| skin | 5% | 7.16 | 93 / 1809 | 33% | 1.40 | 155 / 472 |
| heart | 33% | 38.74 | 283 / 861 | 0% | 0 | 0 / 0 |
| prostate | 12% | 15.93 | 30 / 245 | 8% | 0.16 | 40 / 502 |
| blood vessel | 18% | 36.80 | 239 / 1335 | 0% | 0 | 0 / 0 |
| brain | 7% | 7.26 | 175 / 2642 | 8% | 0.19 | 57 / 705 |
| adrenal gland | 5% | 5.22 | 13 / 258 | 10% | 0.22 | 22 / 230 |
| muscle | 3% | 2.10 | 25 / 803 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 1% | 0.03 | 1 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0010526 | Biological process | retrotransposon silencing |
| GO_0051607 | Biological process | defense response to virus |
| GO_0045869 | Biological process | negative regulation of single stranded viral RNA replication via double stranded DNA intermediate |
| GO_0045071 | Biological process | negative regulation of viral genome replication |
| GO_0016554 | Biological process | cytidine to uridine editing |
| GO_0044355 | Biological process | clearance of foreign intracellular DNA |
| GO_0070383 | Biological process | DNA cytosine deamination |
| GO_0009972 | Biological process | cytidine deamination |
| GO_0044029 | Biological process | positive regulation of gene expression via chromosomal CpG island demethylation |
| GO_0045087 | Biological process | innate immune response |
| GO_0000932 | Cellular component | P-body |
| GO_0005654 | Cellular component | nucleoplasm |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0005515 | Molecular function | protein binding |
| GO_0008270 | Molecular function | zinc ion binding |
| GO_0004126 | Molecular function | cytidine deaminase activity |
| GO_0003723 | Molecular function | RNA binding |
| Gene name | APOBEC3A |
| Protein name | APOBEC3A transcript variant 2 APOBEC3A transcript variant 3 DNA dC->dU-editing enzyme APOBEC-3A (A3A) (EC 3.5.4.38) (Phorbolin-1) APOBEC3A (Apolipoprotein B mRNA editing enzyme, catalytic polypeptide-like 3A) APOBEC3A protein (APOBEC3A transcript variant 1) |
| Synonyms | hCG_1735028 |
| Description | FUNCTION: DNA deaminase (cytidine deaminase) with restriction activity against viruses, foreign DNA and mobility of retrotransposons. Exhibits antiviral activity against adeno-associated virus (AAV) and human T-cell leukemia virus type 1 (HTLV-1) and may inhibit the mobility of LTR and non-LTR retrotransposons. Selectively targets single-stranded DNA and can deaminate both methylcytosine and cytosine in foreign DNA. Can induce somatic hypermutation in the nuclear and mitochondrial DNA. May also play a role in the epigenetic regulation of gene expression through the process of active DNA demethylation. . |
| Accessions | ENST00000249116.7 [P31941-1] A0A0K0MJ49 ENST00000570508.2 [P31941-1] ENST00000402255.5 [P31941-1] P31941 A0A0K0MJ25 B7ZLZ1 A0A0K0MIG1 ENST00000623492.3 [P31941-1] |
