APH1B report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0007220Biological processNotch receptor processing
GO_0034205Biological processamyloid-beta formation
GO_0016485Biological processprotein processing
GO_0031293Biological processmembrane protein intracellular domain proteolysis
GO_0010950Biological processpositive regulation of endopeptidase activity
GO_0007219Biological processNotch signaling pathway
GO_0042987Biological processamyloid precursor protein catabolic process
GO_0010008Cellular componentendosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0070765Cellular componentgamma-secretase complex
GO_0005783Cellular componentendoplasmic reticulum
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0030133Cellular componenttransport vesicle
GO_0061133Molecular functionendopeptidase activator activity
GO_0030674Molecular functionprotein-macromolecule adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAPH1B
Protein nameGamma-secretase subunit APH-1 (APH-1)
Aph-1 homolog B, gamma-secretase subunit
Gamma-secretase subunit APH-1B (APH-1b) (Aph-1beta) (Presenilin-stabilization factor-like)
SynonymsUNQ688/PRO1328
APH-1b
PSFL
DescriptionFUNCTION: Probable subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors and APP (amyloid-beta precursor protein). It probably represents a stabilizing cofactor for the presenilin homodimer that promotes the formation of a stable complex. Probably present in a minority of gamma-secretase complexes compared to APH1A. .

FUNCTION: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. .

FUNCTION: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. .

FUNCTION: Potential subunit of the gamma-secretase complex, an endoprotease complex that catalyzes the intramembrane cleavage of integral proteins such as Notch receptors. .

AccessionsENST00000560890.5
ENST00000560353.1
ENST00000380343.8 [Q8WW43-2]
H0YLT0
ENST00000380340.8
H0YM95
H0YKZ9
ENST00000261879.10 [Q8WW43-1]
Q4R1J8
Q8WW43
ENST00000559971.5