APEX2 report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of APEX2 at tissue level.

III. Associated gene sets

GO_0006310Biological processDNA recombination
GO_0006284Biological processbase-excision repair
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0001650Cellular componentfibrillar center
GO_0005654Cellular componentnucleoplasm
GO_0005739Cellular componentmitochondrion
GO_0005634Cellular componentnucleus
GO_0003906Molecular functionDNA-(apurinic or apyrimidinic site) endonuclease activity
GO_0003677Molecular functionDNA binding
GO_0008311Molecular functiondouble-stranded DNA 3'-5' DNA exonuclease activity
GO_0008081Molecular functionphosphoric diester hydrolase activity
GO_0005515Molecular functionprotein binding
GO_0004519Molecular functionendonuclease activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameAPEX2
Protein nameAlternative protein APEX2
DNA-(apurinic or apyrimidinic site) endonuclease (EC 3.1.-.-)
DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2)
DNA-(apurinic or apyrimidinic site) endonuclease 2 (EC 3.1.11.2) (AP endonuclease XTH2) (APEX nuclease 2) (APEX nuclease-like 2) (Apurinic-apyrimidinic endonuclease 2) (AP endonuclease 2)
SynonymsXTH2
APEXL2
APE2
hCG_18950
DescriptionFUNCTION: Functions as a weak apurinic/apyrimidinic (AP) endodeoxyribonuclease in the DNA base excision repair (BER) pathway of DNA lesions induced by oxidative and alkylating agents . Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. Also displays double-stranded DNA 3'-5' exonuclease, 3'-phosphodiesterase activities . Shows robust 3'-5' exonuclease activity on 3'-recessed heteroduplex DNA and is able to remove mismatched nucleotides preferentially . Also exhibits 3'-5' exonuclease activity on a single nucleotide gap containing heteroduplex DNA and on blunt-ended substrates . Shows fairly strong 3'-phosphodiesterase activity involved in the removal of 3'-damaged termini formed in DNA by oxidative agents . In the nucleus functions in the PCNA-dependent BER pathway . Plays a role in reversing blocked 3' DNA ends, problematic lesions that preclude DNA synthesis . Required for somatic hypermutation (SHM) and DNA cleavage step of class switch recombination (CSR) of immunoglobulin genes (By similarity). Required for proper cell cycle progression during proliferation of peripheral lymphocytes (By similarity). .

FUNCTION: Initiates repair of AP sites in DNA by catalyzing hydrolytic incision of the phosphodiester backbone immediately adjacent to the damage, generating a single-strand break with 5'-deoxyribose phosphate and 3'-hydroxyl ends. .

AccessionsQ9UBZ4
B7ZA71
E5KN95
ENST00000374987.4
L8E820