Name | Number of supported studies | Average coverage | |
---|---|---|---|
non-classical monocyte | 14 studies | 32% ± 18% | |
fibroblast | 9 studies | 22% ± 7% | |
endothelial cell | 8 studies | 22% ± 6% | |
natural killer cell | 8 studies | 19% ± 4% | |
CD16-positive, CD56-dim natural killer cell, human | 7 studies | 21% ± 6% | |
classical monocyte | 7 studies | 26% ± 11% | |
epithelial cell | 6 studies | 26% ± 8% | |
neuron | 4 studies | 27% ± 12% | |
retinal ganglion cell | 4 studies | 46% ± 26% | |
pericyte | 4 studies | 19% ± 3% | |
astrocyte | 4 studies | 21% ± 4% | |
glutamatergic neuron | 4 studies | 40% ± 21% | |
oligodendrocyte | 4 studies | 18% ± 3% | |
CD16-negative, CD56-bright natural killer cell, human | 3 studies | 21% ± 4% | |
myofibroblast cell | 3 studies | 17% ± 1% | |
ciliated cell | 3 studies | 25% ± 8% | |
GABAergic neuron | 3 studies | 38% ± 13% | |
monocyte | 3 studies | 19% ± 2% | |
macrophage | 3 studies | 19% ± 3% | |
basal cell | 3 studies | 22% ± 2% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
esophagus | 100% | 7163.02 | 1445 / 1445 | 100% | 51.09 | 183 / 183 |
skin | 100% | 9255.88 | 1809 / 1809 | 100% | 55.27 | 472 / 472 |
ovary | 100% | 9414.88 | 180 / 180 | 100% | 39.45 | 428 / 430 |
stomach | 100% | 4959.42 | 358 / 359 | 100% | 44.40 | 285 / 286 |
thymus | 100% | 5662.36 | 652 / 653 | 100% | 36.51 | 602 / 605 |
uterus | 100% | 9002.86 | 170 / 170 | 99% | 47.87 | 456 / 459 |
brain | 99% | 7573.23 | 2624 / 2642 | 100% | 56.03 | 705 / 705 |
breast | 100% | 7239.77 | 459 / 459 | 99% | 44.23 | 1110 / 1118 |
intestine | 100% | 6442.81 | 966 / 966 | 99% | 43.57 | 523 / 527 |
lung | 100% | 6550.06 | 577 / 578 | 99% | 39.78 | 1148 / 1155 |
prostate | 100% | 5925.17 | 245 / 245 | 99% | 32.58 | 498 / 502 |
adrenal gland | 100% | 14611.53 | 258 / 258 | 99% | 52.04 | 228 / 230 |
bladder | 100% | 7585.86 | 21 / 21 | 99% | 46.42 | 499 / 504 |
liver | 100% | 4477.74 | 225 / 226 | 99% | 33.82 | 402 / 406 |
kidney | 100% | 5059.70 | 89 / 89 | 98% | 30.81 | 884 / 901 |
pancreas | 97% | 3266.38 | 318 / 328 | 99% | 41.63 | 177 / 178 |
adipose | 100% | 7891.07 | 1204 / 1204 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 100% | 57.09 | 80 / 80 |
lymph node | 0% | 0 | 0 / 0 | 100% | 38.99 | 29 / 29 |
muscle | 100% | 8403.33 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 7885.32 | 241 / 241 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 100% | 48.22 | 45 / 45 |
ureter | 0% | 0 | 0 / 0 | 100% | 21.83 | 1 / 1 |
blood vessel | 100% | 7244.96 | 1334 / 1335 | 0% | 0 | 0 / 0 |
peripheral blood | 100% | 6498.28 | 928 / 929 | 0% | 0 | 0 / 0 |
heart | 98% | 5488.63 | 846 / 861 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006897 | Biological process | endocytosis |
GO_0010976 | Biological process | positive regulation of neuron projection development |
GO_0098884 | Biological process | postsynaptic neurotransmitter receptor internalization |
GO_0006886 | Biological process | intracellular protein transport |
GO_0048260 | Biological process | positive regulation of receptor-mediated endocytosis |
GO_0016192 | Biological process | vesicle-mediated transport |
GO_0072583 | Biological process | clathrin-dependent endocytosis |
GO_1900126 | Biological process | negative regulation of hyaluronan biosynthetic process |
GO_0006895 | Biological process | Golgi to endosome transport |
GO_0016324 | Cellular component | apical plasma membrane |
GO_0005886 | Cellular component | plasma membrane |
GO_0030122 | Cellular component | AP-2 adaptor complex |
GO_0016020 | Cellular component | membrane |
GO_0030666 | Cellular component | endocytic vesicle membrane |
GO_0009898 | Cellular component | cytoplasmic side of plasma membrane |
GO_0032433 | Cellular component | filopodium tip |
GO_0030669 | Cellular component | clathrin-coated endocytic vesicle membrane |
GO_0098794 | Cellular component | postsynapse |
GO_0030130 | Cellular component | clathrin coat of trans-Golgi network vesicle |
GO_0005829 | Cellular component | cytosol |
GO_0045334 | Cellular component | clathrin-coated endocytic vesicle |
GO_0016323 | Cellular component | basolateral plasma membrane |
GO_0036020 | Cellular component | endolysosome membrane |
GO_0044877 | Molecular function | protein-containing complex binding |
GO_0019901 | Molecular function | protein kinase binding |
GO_0050750 | Molecular function | low-density lipoprotein particle receptor binding |
GO_0035615 | Molecular function | clathrin adaptor activity |
GO_0005515 | Molecular function | protein binding |
Gene name | AP2A1 |
Protein name | Adaptor related protein complex 2 subunit alpha 1 AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit) |
Synonyms | ADTAA CLAPA1 |
Description | FUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 . The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). . |
Accessions | M0R2D9 ENST00000597774.5 ENST00000354293.10 [O95782-2] ENST00000359032.10 [O95782-1] O95782 |