AP2A1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006897Biological processendocytosis
GO_0010976Biological processpositive regulation of neuron projection development
GO_0098884Biological processpostsynaptic neurotransmitter receptor internalization
GO_0006886Biological processintracellular protein transport
GO_0048260Biological processpositive regulation of receptor-mediated endocytosis
GO_0016192Biological processvesicle-mediated transport
GO_0072583Biological processclathrin-dependent endocytosis
GO_1900126Biological processnegative regulation of hyaluronan biosynthetic process
GO_0006895Biological processGolgi to endosome transport
GO_0016324Cellular componentapical plasma membrane
GO_0005886Cellular componentplasma membrane
GO_0030122Cellular componentAP-2 adaptor complex
GO_0016020Cellular componentmembrane
GO_0030666Cellular componentendocytic vesicle membrane
GO_0009898Cellular componentcytoplasmic side of plasma membrane
GO_0032433Cellular componentfilopodium tip
GO_0030669Cellular componentclathrin-coated endocytic vesicle membrane
GO_0098794Cellular componentpostsynapse
GO_0030130Cellular componentclathrin coat of trans-Golgi network vesicle
GO_0005829Cellular componentcytosol
GO_0045334Cellular componentclathrin-coated endocytic vesicle
GO_0016323Cellular componentbasolateral plasma membrane
GO_0036020Cellular componentendolysosome membrane
GO_0044877Molecular functionprotein-containing complex binding
GO_0019901Molecular functionprotein kinase binding
GO_0050750Molecular functionlow-density lipoprotein particle receptor binding
GO_0035615Molecular functionclathrin adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameAP2A1
Protein nameAdaptor related protein complex 2 subunit alpha 1
AP-2 complex subunit alpha-1 (100 kDa coated vesicle protein A) (Adaptor protein complex AP-2 subunit alpha-1) (Adaptor-related protein complex 2 subunit alpha-1) (Alpha-adaptin A) (Alpha1-adaptin) (Clathrin assembly protein complex 2 alpha-A large chain) (Plasma membrane adaptor HA2/AP2 adaptin alpha A subunit)
SynonymsADTAA
CLAPA1
DescriptionFUNCTION: Component of the adaptor protein complex 2 (AP-2). Adaptor protein complexes function in protein transport via transport vesicles in different membrane traffic pathways. Adaptor protein complexes are vesicle coat components and appear to be involved in cargo selection and vesicle formation. AP-2 is involved in clathrin-dependent endocytosis in which cargo proteins are incorporated into vesicles surrounded by clathrin (clathrin-coated vesicles, CCVs) which are destined for fusion with the early endosome. The clathrin lattice serves as a mechanical scaffold but is itself unable to bind directly to membrane components. Clathrin-associated adaptor protein (AP) complexes which can bind directly to both the clathrin lattice and to the lipid and protein components of membranes are considered to be the major clathrin adaptors contributing the CCV formation. AP-2 also serves as a cargo receptor to selectively sort the membrane proteins involved in receptor-mediated endocytosis. AP-2 seems to play a role in the recycling of synaptic vesicle membranes from the presynaptic surface. AP-2 recognizes Y-X-X-[FILMV] (Y-X-X-Phi) and [ED]-X-X-X-L-[LI] endocytosis signal motifs within the cytosolic tails of transmembrane cargo molecules. AP-2 may also play a role in maintaining normal post-endocytic trafficking through the ARF6-regulated, non-clathrin pathway. During long-term potentiation in hippocampal neurons, AP-2 is responsible for the endocytosis of ADAM10 . The AP-2 alpha subunit binds polyphosphoinositide-containing lipids, positioning AP-2 on the membrane. The AP-2 alpha subunit acts via its C-terminal appendage domain as a scaffolding platform for endocytic accessory proteins. The AP-2 alpha and AP-2 sigma subunits are thought to contribute to the recognition of the [ED]-X-X-X-L-[LI] motif (By similarity). .

AccessionsM0R2D9
ENST00000597774.5
ENST00000354293.10 [O95782-2]
ENST00000359032.10 [O95782-1]
O95782