ANKFY1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0048549Biological processpositive regulation of pinocytosis
GO_0006897Biological processendocytosis
GO_0042147Biological processretrograde transport, endosome to Golgi
GO_0016197Biological processendosomal transport
GO_0090160Biological processGolgi to lysosome transport
GO_0034058Biological processendosomal vesicle fusion
GO_0016020Cellular componentmembrane
GO_0005769Cellular componentearly endosome
GO_0044354Cellular componentmacropinosome
GO_0070062Cellular componentextracellular exosome
GO_0030904Cellular componentretromer complex
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0010008Cellular componentendosome membrane
GO_0005768Cellular componentendosome
GO_0005765Cellular componentlysosomal membrane
GO_0031267Molecular functionsmall GTPase binding
GO_0046872Molecular functionmetal ion binding
GO_1901981Molecular functionphosphatidylinositol phosphate binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameANKFY1
Protein nameAnkyrin repeat and FYVE domain containing 1
Rabankyrin-5 (Rank-5) (Ankyrin repeat and FYVE domain-containing protein 1) (Ankyrin repeats hooked to a zinc finger motif)
SynonymsKIAA1255
ANKHZN
DescriptionFUNCTION: Proposed effector of Rab5. Binds to phosphatidylinositol 3-phosphate (PI(3)P). Involved in homotypic early endosome fusion and to a lesser extent in heterotypic fusion of chlathrin-coated vesicles with early endosomes. Involved in macropinocytosis; the function is dependent on Rab5-GTP. Required for correct endosomal localization. Involved in the internalization and trafficking of activated tyrosine kinase receptors such as PDGFRB. Regulates the subcellular localization of the retromer complex in a EHD1-dependent manner. Involved in endosome-to-Golgi transport and biosynthetic transport to late endosomes and lysosomes indicative for a regulation of retromer complex-mediated retrograde transport. .

AccessionsENST00000570535.5 [Q9P2R3-4]
ENST00000341657.9 [Q9P2R3-1]
Q9P2R3
ENST00000574736.1
K7EPT2
ENST00000648043.1 [Q9P2R3-1]
ENST00000575298.1
ENST00000574367.5 [Q9P2R3-2]
I3L1Z9
I3L3P8
ENST00000572412.5