Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| mesothelial cell | 10 studies | 54% ± 23% | |
| fibroblast | 9 studies | 26% ± 12% | |
| endothelial cell | 5 studies | 22% ± 7% | |
| hepatocyte | 4 studies | 66% ± 24% | |
| Mueller cell | 4 studies | 46% ± 1% | |
| endothelial cell of lymphatic vessel | 4 studies | 19% ± 4% | |
| cholangiocyte | 3 studies | 39% ± 23% | |
| monocyte | 3 studies | 32% ± 19% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| liver | 3 studies | 31% ± 9% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| prostate | 100% | 3535.42 | 245 / 245 | 95% | 7.97 | 476 / 502 |
| kidney | 100% | 2335.65 | 89 / 89 | 67% | 10.40 | 606 / 901 |
| uterus | 100% | 8173.24 | 170 / 170 | 56% | 9.12 | 256 / 459 |
| ovary | 99% | 2501.64 | 178 / 180 | 54% | 8.46 | 232 / 430 |
| lung | 94% | 1030.29 | 546 / 578 | 43% | 3.00 | 493 / 1155 |
| bladder | 81% | 660.86 | 17 / 21 | 52% | 6.67 | 263 / 504 |
| breast | 97% | 1139.35 | 447 / 459 | 35% | 0.96 | 388 / 1118 |
| liver | 69% | 318.74 | 155 / 226 | 55% | 1.87 | 222 / 406 |
| adipose | 98% | 2439.12 | 1178 / 1204 | 0% | 0 | 0 / 0 |
| heart | 95% | 2202.57 | 822 / 861 | 0% | 0 | 0 / 0 |
| adrenal gland | 74% | 574.46 | 192 / 258 | 20% | 5.47 | 46 / 230 |
| pancreas | 27% | 122.55 | 90 / 328 | 62% | 4.44 | 110 / 178 |
| esophagus | 59% | 688.75 | 848 / 1445 | 16% | 0.71 | 29 / 183 |
| muscle | 74% | 434.80 | 598 / 803 | 0% | 0 | 0 / 0 |
| blood vessel | 70% | 614.30 | 932 / 1335 | 0% | 0 | 0 / 0 |
| brain | 11% | 71.66 | 297 / 2642 | 53% | 1.26 | 376 / 705 |
| skin | 38% | 175.69 | 680 / 1809 | 25% | 2.31 | 117 / 472 |
| spleen | 56% | 337.56 | 135 / 241 | 0% | 0 | 0 / 0 |
| thymus | 38% | 185.32 | 246 / 653 | 17% | 0.49 | 102 / 605 |
| intestine | 33% | 158.80 | 319 / 966 | 20% | 1.42 | 104 / 527 |
| eye | 0% | 0 | 0 / 0 | 36% | 1.15 | 29 / 80 |
| stomach | 12% | 55.20 | 44 / 359 | 16% | 1.36 | 46 / 286 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 2.51 | 7 / 45 |
| peripheral blood | 4% | 20.74 | 40 / 929 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 29 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0071300 | Biological process | cellular response to retinoic acid |
| GO_0009855 | Biological process | determination of bilateral symmetry |
| GO_0032355 | Biological process | response to estradiol |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0009954 | Biological process | proximal/distal pattern formation |
| GO_0030324 | Biological process | lung development |
| GO_0008283 | Biological process | cell population proliferation |
| GO_0031016 | Biological process | pancreas development |
| GO_0034097 | Biological process | response to cytokine |
| GO_0007494 | Biological process | midgut development |
| GO_0048566 | Biological process | embryonic digestive tract development |
| GO_0010628 | Biological process | positive regulation of gene expression |
| GO_0001822 | Biological process | kidney development |
| GO_0001889 | Biological process | liver development |
| GO_0033189 | Biological process | response to vitamin A |
| GO_0042573 | Biological process | retinoic acid metabolic process |
| GO_0035115 | Biological process | embryonic forelimb morphogenesis |
| GO_0042904 | Biological process | 9-cis-retinoic acid biosynthetic process |
| GO_0014032 | Biological process | neural crest cell development |
| GO_0016331 | Biological process | morphogenesis of embryonic epithelium |
| GO_1905562 | Biological process | regulation of vascular endothelial cell proliferation |
| GO_0030182 | Biological process | neuron differentiation |
| GO_0006776 | Biological process | vitamin A metabolic process |
| GO_0042574 | Biological process | retinal metabolic process |
| GO_0035799 | Biological process | ureter maturation |
| GO_0060324 | Biological process | face development |
| GO_0042572 | Biological process | retinol metabolic process |
| GO_0031076 | Biological process | embryonic camera-type eye development |
| GO_0001568 | Biological process | blood vessel development |
| GO_0002138 | Biological process | retinoic acid biosynthetic process |
| GO_0048738 | Biological process | cardiac muscle tissue development |
| GO_0030902 | Biological process | hindbrain development |
| GO_0008284 | Biological process | positive regulation of cell population proliferation |
| GO_0032526 | Biological process | response to retinoic acid |
| GO_0021983 | Biological process | pituitary gland development |
| GO_0021915 | Biological process | neural tube development |
| GO_0043065 | Biological process | positive regulation of apoptotic process |
| GO_0003007 | Biological process | heart morphogenesis |
| GO_0051289 | Biological process | protein homotetramerization |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0004028 | Molecular function | 3-chloroallyl aldehyde dehydrogenase activity |
| GO_0004029 | Molecular function | aldehyde dehydrogenase (NAD+) activity |
| GO_0001758 | Molecular function | retinal dehydrogenase activity |
| GO_0016918 | Molecular function | retinal binding |
| Gene name | ALDH1A2 |
| Protein name | Aldehyde dehydrogenase 1 family member A2 Retinal dehydrogenase 2 (RALDH 2) (RalDH2) (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (ALDH1A2) (Retinaldehyde-specific dehydrogenase type 2) (RALDH(II)) Retinal dehydrogenase 2 (EC 1.2.1.36) (Aldehyde dehydrogenase family 1 member A2) (Retinaldehyde-specific dehydrogenase type 2) Aldehyde dehydrogenase 1 family member A2 (RALDH2-T) |
| Synonyms | RALDH2 |
| Description | FUNCTION: Catalyzes the NAD-dependent oxidation of aldehyde substrates, such as all-trans-retinal and all-trans-13,14-dihydroretinal, to their corresponding carboxylic acids, all-trans-retinoate and all-trans-13,14-dihydroretinoate, respectively . Retinoate signaling is critical for the transcriptional control of many genes, for instance it is crucial for initiation of meiosis in both male and female (Probable). Recognizes retinal as substrate, both in its free form and when bound to cellular retinol-binding protein (By similarity). Can metabolize octanal and decanal, but has only very low activity with benzaldehyde, acetaldehyde and propanal (By similarity). Displays complete lack of activity with citral (By similarity). . |
| Accessions | H0YMG7 A0A0G2JL97 ENST00000557967.5 ENST00000558231.5 ENST00000537372.5 [O94788-3] ENST00000558239.5 O94788 H0YKL3 ENST00000559517.5 [O94788-4] ENST00000558384.1 H0YMT5 Q9UED3 ENST00000249750.9 [O94788-1] E9PF31 ENST00000430119.6 ENST00000561070.5 ENST00000347587.7 [O94788-2] |
