AICDA | OmnibusX

sc-RNAseq data

Insufficient scRNA-seq data for expression of AICDA at tissue level.

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
spleen	94%	33.89	227 / 241	0%	0	0 / 0
lymph node	0%	0	0 / 0	90%	77.52	26 / 29
adipose	83%	21.75	1005 / 1204	0%	0	0 / 0
uterus	76%	14.56	130 / 170	1%	0.05	6 / 459
lung	72%	9.03	414 / 578	5%	0.16	59 / 1155
peripheral blood	69%	1585.40	638 / 929	0%	0	0 / 0
breast	64%	8.69	296 / 459	3%	0.55	33 / 1118
intestine	55%	23.08	527 / 966	4%	0.37	19 / 527
esophagus	51%	5.77	735 / 1445	5%	0.13	10 / 183
skin	45%	4.89	809 / 1809	8%	0.38	40 / 472
blood vessel	53%	6.33	706 / 1335	0%	0	0 / 0
heart	44%	3.93	381 / 861	0%	0	0 / 0
kidney	24%	1.83	21 / 89	17%	0.59	153 / 901
bladder	33%	2.29	7 / 21	1%	0.17	7 / 504
thymus	28%	7.10	186 / 653	5%	0.60	32 / 605
muscle	33%	2.33	261 / 803	0%	0	0 / 0
stomach	20%	1.47	73 / 359	4%	0.48	12 / 286
prostate	15%	3.11	37 / 245	1%	0.03	4 / 502
tonsil	0%	0	0 / 0	16%	0.46	7 / 45
adrenal gland	13%	0.73	34 / 258	0%	0	0 / 230
pancreas	5%	0.38	18 / 328	6%	0.52	11 / 178
liver	5%	0.44	12 / 226	1%	0.03	4 / 406
ovary	6%	0.51	11 / 180	0%	0	0 / 430
brain	3%	0.21	89 / 2642	0%	0.11	2 / 705
eye	0%	0	0 / 0	1%	0.01	1 / 80
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0
ureter	0%	0	0 / 0	0%	0	0 / 1

GO_0045869	Biological process	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate
GO_0006397	Biological process	mRNA processing
GO_0051607	Biological process	defense response to virus
GO_0070383	Biological process	DNA cytosine deamination
GO_0009972	Biological process	cytidine deamination
GO_0016554	Biological process	cytidine to uridine editing
GO_0016445	Biological process	somatic diversification of immunoglobulins
GO_0042742	Biological process	defense response to bacterium
GO_0071222	Biological process	cellular response to lipopolysaccharide
GO_0033262	Biological process	regulation of nuclear cell cycle DNA replication
GO_0045190	Biological process	isotype switching
GO_0016446	Biological process	somatic hypermutation of immunoglobulin genes
GO_0044029	Biological process	positive regulation of gene expression via chromosomal CpG island demethylation
GO_0030183	Biological process	B cell differentiation
GO_0032991	Cellular component	protein-containing complex
GO_0000932	Cellular component	P-body
GO_0005829	Cellular component	cytosol
GO_0005737	Cellular component	cytoplasm
GO_0005634	Cellular component	nucleus
GO_0031625	Molecular function	ubiquitin protein ligase binding
GO_0042802	Molecular function	identical protein binding
GO_0004126	Molecular function	cytidine deaminase activity
GO_0008270	Molecular function	zinc ion binding
GO_0003723	Molecular function	RNA binding
GO_0005515	Molecular function	protein binding

Gene name	AICDA
Protein name	AID (Activation-induced cytidine deaminase) (Epididymis secretory protein Li 284) Single-stranded DNA cytosine deaminase (EC 3.5.4.38) (Activation-induced cytidine deaminase) (AID) (Cytidine aminohydrolase) Activation-induced deaminase Activation-induced cytidine deaminase Activation induced cytidine deaminase
Synonyms	AID hCG_25220 HEL-S-284
Description	FUNCTION: Single-stranded DNA-specific cytidine deaminase. Involved in somatic hypermutation (SHM), gene conversion, and class-switch recombination (CSR) in B-lymphocytes by deaminating C to U during transcription of Ig-variable (V) and Ig-switch (S) region DNA. Required for several crucial steps of B-cell terminal differentiation necessary for efficient antibody responses . May also play a role in the epigenetic regulation of gene expression by participating in DNA demethylation . .
Accessions	Q9GZX7 ENST00000229335.11 [Q9GZX7-1] ENST00000543081.6 Q546Y9 Q5XM85 ENST00000696246.1 Q6QJ80 Q6QLN7 A0A8Q3SII6 ENST00000696272.1 A0A8Q3WL45 ENST00000544516.6 Q6QHI9 ENST00000537228.6 [Q9GZX7-2] ENST00000696273.1 A0A8Q3SIK8

AICDA report