AGK report

I. Expression across cell types

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of AGK at tissue level.

III. Associated gene sets

GO_0046486Biological processglycerolipid metabolic process
GO_0045039Biological processprotein insertion into mitochondrial inner membrane
GO_0046834Biological processlipid phosphorylation
GO_0046513Biological processceramide biosynthetic process
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0005741Cellular componentmitochondrial outer membrane
GO_0031966Cellular componentmitochondrial membrane
GO_0042721Cellular componentTIM22 mitochondrial import inner membrane insertion complex
GO_0005758Cellular componentmitochondrial intermembrane space
GO_0005829Cellular componentcytosol
GO_0005743Cellular componentmitochondrial inner membrane
GO_0005739Cellular componentmitochondrion
GO_0047620Molecular functionacylglycerol kinase activity
GO_0004143Molecular functionATP-dependent diacylglycerol kinase activity
GO_0102773Molecular functiondihydroceramide kinase activity
GO_0005515Molecular functionprotein binding
GO_0005524Molecular functionATP binding
GO_0001729Molecular functionceramide kinase activity

IV. Literature review

[source]
Gene nameAGK
Protein nameAcylglycerol kinase, mitochondrial
Acylglycerol kinase, mitochondrial (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase)
Acylglycerol kinase
Acylglycerol kinase, mitochondrial (hAGK) (EC 2.7.1.107) (EC 2.7.1.138) (EC 2.7.1.94) (Multiple substrate lipid kinase) (HsMuLK) (MuLK) (Multi-substrate lipid kinase)
SynonymsMULK
DescriptionFUNCTION: Lipid kinase that can phosphorylate both monoacylglycerol and diacylglycerol to form lysophosphatidic acid (LPA) and phosphatidic acid (PA), respectively . Does not phosphorylate sphingosine . Phosphorylates ceramide (By similarity). Phosphorylates 1,2-dioleoylglycerol more rapidly than 2,3-dioleoylglycerol (By similarity). Independently of its lipid kinase activity, acts as a component of the TIM22 complex . The TIM22 complex mediates the import and insertion of multi-pass transmembrane proteins into the mitochondrial inner membrane by forming a twin-pore translocase that uses the membrane potential as the external driving force . In the TIM22 complex, required for the import of a subset of metabolite carriers into mitochondria, such as ANT1/SLC25A4 and SLC25A24, while it is not required for the import of TIMM23 . Overexpression increases the formation and secretion of LPA, resulting in transactivation of EGFR and activation of the downstream MAPK signaling pathway, leading to increased cell growth . .

AccessionsA0A3B3ITD0
A0A3B3ISY9
ENST00000494688.1
ENST00000573706.5
ENST00000650365.1
A0A0G2JLD0
A0A3B3IUC9
A0A3B3IS09
ENST00000492693.5 [Q53H12-2]
A0A3B3ITV0
A0A3B3ISZ0
ENST00000473247.5
ENST00000648690.1
ENST00000648068.1 [Q53H12-1]
ENST00000649014.1
ENST00000650006.1
Q53H12
A0A3B3IRM6
E9PG39
ENST00000649790.1
A0A0G2JLG5
ENST00000473884.5
ENST00000649286.2 [Q53H12-1]
ENST00000648395.1
ENST00000647568.1
ENST00000629555.2
A0A3B3ITX7
ENST00000575872.2
ENST00000650547.1 [Q53H12-1]
F8WDD1
ENST00000573803.5
ENST00000649365.1
E9PC15
ENST00000649914.1