AGBL4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0035609Biological processC-terminal protein deglutamylation
GO_0008285Biological processnegative regulation of cell population proliferation
GO_0120222Biological processregulation of blastocyst development
GO_0051607Biological processdefense response to virus
GO_0035610Biological processprotein side chain deglutamylation
GO_0098957Biological processanterograde axonal transport of mitochondrion
GO_2000060Biological processpositive regulation of ubiquitin-dependent protein catabolic process
GO_0098958Biological processretrograde axonal transport of mitochondrion
GO_0006508Biological processproteolysis
GO_0021954Biological processcentral nervous system neuron development
GO_0035608Biological processprotein deglutamylation
GO_0005794Cellular componentGolgi apparatus
GO_0005814Cellular componentcentriole
GO_0005829Cellular componentcytosol
GO_0036064Cellular componentciliary basal body
GO_1904115Cellular componentaxon cytoplasm
GO_0015631Molecular functiontubulin binding
GO_0004181Molecular functionmetallocarboxypeptidase activity
GO_0008270Molecular functionzinc ion binding

IV. Literature review

[source]
Gene nameAGBL4
Protein nameAGBL carboxypeptidase 4
ATP/GTP binding protein-like 4
Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6)
SynonymsCCP6
DescriptionFUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis . .

AccessionsB1AMW3
A0AVJ2
ENST00000416121.5
ENST00000371838.5
B1ANV5
ENST00000371839.6 [Q5VU57-1]
Q5VU57
H0Y5X4
ENST00000371836.1