Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| astrocyte | 17 studies | 45% ± 21% | |
| glutamatergic neuron | 12 studies | 75% ± 24% | |
| GABAergic neuron | 10 studies | 65% ± 25% | |
| oligodendrocyte precursor cell | 10 studies | 32% ± 13% | |
| adipocyte | 9 studies | 39% ± 15% | |
| ciliated cell | 8 studies | 51% ± 34% | |
| microglial cell | 7 studies | 38% ± 24% | |
| interneuron | 6 studies | 60% ± 31% | |
| neuron | 5 studies | 48% ± 14% | |
| endothelial cell | 5 studies | 41% ± 20% | |
| cardiac muscle cell | 5 studies | 23% ± 4% | |
| retinal cone cell | 5 studies | 78% ± 30% | |
| mesothelial cell | 4 studies | 22% ± 6% | |
| retinal ganglion cell | 4 studies | 67% ± 21% | |
| retinal rod cell | 4 studies | 78% ± 11% | |
| endothelial cell of lymphatic vessel | 4 studies | 29% ± 6% | |
| type II pneumocyte | 4 studies | 20% ± 4% | |
| GABAergic interneuron | 3 studies | 71% ± 7% | |
| epithelial cell | 3 studies | 52% ± 28% | |
| granule cell | 3 studies | 43% ± 37% | |
| ependymal cell | 3 studies | 89% ± 6% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 95% | 258.46 | 2497 / 2642 | 36% | 0.89 | 254 / 705 |
| thymus | 97% | 69.10 | 631 / 653 | 15% | 0.21 | 88 / 605 |
| kidney | 99% | 102.24 | 88 / 89 | 6% | 0.10 | 53 / 901 |
| adrenal gland | 40% | 18.19 | 104 / 258 | 56% | 1.50 | 128 / 230 |
| breast | 54% | 20.04 | 249 / 459 | 12% | 0.19 | 129 / 1118 |
| liver | 61% | 39.84 | 137 / 226 | 1% | 0.04 | 5 / 406 |
| heart | 56% | 47.83 | 484 / 861 | 0% | 0 | 0 / 0 |
| skin | 48% | 19.98 | 863 / 1809 | 2% | 0.03 | 8 / 472 |
| ovary | 41% | 12.69 | 74 / 180 | 6% | 0.08 | 26 / 430 |
| adipose | 37% | 12.83 | 442 / 1204 | 0% | 0 | 0 / 0 |
| lung | 32% | 18.09 | 187 / 578 | 4% | 0.07 | 43 / 1155 |
| uterus | 22% | 9.28 | 38 / 170 | 5% | 0.10 | 24 / 459 |
| prostate | 24% | 7.09 | 60 / 245 | 2% | 0.03 | 8 / 502 |
| intestine | 22% | 6.31 | 214 / 966 | 1% | 0.02 | 7 / 527 |
| spleen | 20% | 5.79 | 49 / 241 | 0% | 0 | 0 / 0 |
| stomach | 16% | 4.84 | 57 / 359 | 2% | 0.05 | 5 / 286 |
| pancreas | 13% | 3.27 | 42 / 328 | 4% | 0.11 | 7 / 178 |
| blood vessel | 13% | 3.58 | 172 / 1335 | 0% | 0 | 0 / 0 |
| bladder | 10% | 1.95 | 2 / 21 | 3% | 0.06 | 13 / 504 |
| esophagus | 5% | 1.28 | 73 / 1445 | 2% | 0.02 | 3 / 183 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.07 | 4 / 80 |
| lymph node | 0% | 0 | 0 / 0 | 3% | 0.08 | 1 / 29 |
| peripheral blood | 1% | 0.52 | 10 / 929 | 0% | 0 | 0 / 0 |
| muscle | 0% | 0.10 | 3 / 803 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 45 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0035609 | Biological process | C-terminal protein deglutamylation |
| GO_0008285 | Biological process | negative regulation of cell population proliferation |
| GO_0120222 | Biological process | regulation of blastocyst development |
| GO_0051607 | Biological process | defense response to virus |
| GO_0035610 | Biological process | protein side chain deglutamylation |
| GO_0098957 | Biological process | anterograde axonal transport of mitochondrion |
| GO_2000060 | Biological process | positive regulation of ubiquitin-dependent protein catabolic process |
| GO_0098958 | Biological process | retrograde axonal transport of mitochondrion |
| GO_0006508 | Biological process | proteolysis |
| GO_0021954 | Biological process | central nervous system neuron development |
| GO_0035608 | Biological process | protein deglutamylation |
| GO_0005794 | Cellular component | Golgi apparatus |
| GO_0005814 | Cellular component | centriole |
| GO_0005829 | Cellular component | cytosol |
| GO_0036064 | Cellular component | ciliary basal body |
| GO_1904115 | Cellular component | axon cytoplasm |
| GO_0015631 | Molecular function | tubulin binding |
| GO_0004181 | Molecular function | metallocarboxypeptidase activity |
| GO_0008270 | Molecular function | zinc ion binding |
| Gene name | AGBL4 |
| Protein name | AGBL carboxypeptidase 4 ATP/GTP binding protein-like 4 Cytosolic carboxypeptidase 6 (EC 3.4.17.24) (ATP/GTP-binding protein-like 4) (Protein deglutamylase CCP6) |
| Synonyms | CCP6 |
| Description | FUNCTION: Metallocarboxypeptidase that mediates protein deglutamylation of tubulin and non-tubulin target proteins. Catalyzes the removal of polyglutamate side chains present on the gamma-carboxyl group of glutamate residues within the C-terminal tail of tubulin protein. Specifically cleaves tubulin long-side-chains, while it is not able to remove the branching point glutamate. Also catalyzes the removal of polyglutamate residues from the carboxy-terminus of non-tubulin proteins such as MYLK. Mediates the deglutamylation of nucleotidyltransferase CGAS, leading to CGAS antiviral defense response activation (By similarity). Involved in KLF4 deglutamylation which promotes KLF4 proteasome-mediated degradation, thereby negatively regulating cell pluripotency maintenance and embryogenesis . . |
| Accessions | B1AMW3 A0AVJ2 ENST00000416121.5 ENST00000371838.5 B1ANV5 ENST00000371839.6 [Q5VU57-1] Q5VU57 H0Y5X4 ENST00000371836.1 |