Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| endothelial cell | 24 studies | 28% ± 8% | |
| endothelial cell of lymphatic vessel | 16 studies | 25% ± 8% | |
| capillary endothelial cell | 11 studies | 26% ± 8% | |
| vein endothelial cell | 11 studies | 31% ± 11% | |
| endothelial cell of artery | 10 studies | 32% ± 15% | |
| endothelial cell of vascular tree | 6 studies | 26% ± 8% |
Insufficient scRNA-seq data for expression of ADCY4 at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| thymus | 100% | 5028.80 | 653 / 653 | 99% | 5.65 | 599 / 605 |
| prostate | 100% | 3719.65 | 244 / 245 | 96% | 3.57 | 480 / 502 |
| breast | 100% | 8668.90 | 459 / 459 | 95% | 4.49 | 1062 / 1118 |
| esophagus | 98% | 3128.75 | 1415 / 1445 | 93% | 3.52 | 170 / 183 |
| intestine | 98% | 2348.91 | 948 / 966 | 92% | 3.01 | 486 / 527 |
| lung | 100% | 5712.42 | 578 / 578 | 90% | 2.88 | 1036 / 1155 |
| bladder | 100% | 3642.57 | 21 / 21 | 88% | 2.63 | 446 / 504 |
| stomach | 93% | 1743.54 | 335 / 359 | 93% | 3.27 | 266 / 286 |
| uterus | 100% | 6387.52 | 170 / 170 | 83% | 2.50 | 380 / 459 |
| kidney | 100% | 3648.90 | 89 / 89 | 78% | 6.26 | 704 / 901 |
| adrenal gland | 87% | 1279.63 | 225 / 258 | 86% | 3.46 | 198 / 230 |
| pancreas | 41% | 461.81 | 135 / 328 | 99% | 6.12 | 177 / 178 |
| skin | 71% | 1592.66 | 1279 / 1809 | 67% | 1.68 | 315 / 472 |
| ovary | 65% | 1234.55 | 117 / 180 | 70% | 2.24 | 303 / 430 |
| brain | 26% | 265.48 | 680 / 2642 | 91% | 2.28 | 639 / 705 |
| adipose | 100% | 8612.02 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| spleen | 100% | 5378.70 | 241 / 241 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 100% | 1.69 | 1 / 1 |
| heart | 100% | 3717.53 | 860 / 861 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 93% | 2.74 | 27 / 29 |
| liver | 12% | 130.99 | 26 / 226 | 79% | 1.99 | 321 / 406 |
| muscle | 90% | 1331.08 | 721 / 803 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 89% | 1.74 | 40 / 45 |
| blood vessel | 79% | 1994.41 | 1052 / 1335 | 0% | 0 | 0 / 0 |
| peripheral blood | 36% | 367.80 | 334 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 8% | 0.11 | 6 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0035556 | Biological process | intracellular signal transduction |
| GO_0006171 | Biological process | cAMP biosynthetic process |
| GO_0007188 | Biological process | adenylate cyclase-modulating G protein-coupled receptor signaling pathway |
| GO_0007193 | Biological process | adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway |
| GO_0007189 | Biological process | adenylate cyclase-activating G protein-coupled receptor signaling pathway |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0030425 | Cellular component | dendrite |
| GO_0005080 | Molecular function | protein kinase C binding |
| GO_0004016 | Molecular function | adenylate cyclase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0046872 | Molecular function | metal ion binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ADCY4 |
| Protein name | adenylate cyclase (EC 4.6.1.1) Adenylate cyclase 4 Adenylate cyclase type 4 (EC 4.6.1.1) (ATP pyrophosphate-lyase 4) (Adenylate cyclase type IV) (Adenylyl cyclase 4) |
| Synonyms | |
| Description | FUNCTION: Catalyzes the formation of the signaling molecule cAMP in response to G-protein signaling. . |
| Accessions | H0YJ57 Q96KY6 ENST00000646612.1 [Q8NFM4-1] ENST00000559167.5 ENST00000418030.7 [Q8NFM4-1] ENST00000310677.8 [Q8NFM4-1] ENST00000557056.5 ENST00000556932.1 ENST00000642645.1 [Q8NFM4-1] ENST00000644961.1 [Q8NFM4-1] ENST00000554781.5 H0YN72 ENST00000561138.1 G3V258 H0YLM0 Q8NFM4 G3V262 ENST00000554068.6 [Q8NFM4-1] |