Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| adipocyte | 10 studies | 59% ± 15% | |
| oligodendrocyte | 10 studies | 28% ± 9% | |
| goblet cell | 7 studies | 28% ± 7% | |
| epithelial cell | 7 studies | 23% ± 8% | |
| type II pneumocyte | 6 studies | 40% ± 11% | |
| cardiac muscle cell | 5 studies | 26% ± 6% | |
| hepatocyte | 5 studies | 30% ± 20% | |
| type I pneumocyte | 5 studies | 19% ± 3% | |
| endothelial cell | 4 studies | 23% ± 11% | |
| retinal ganglion cell | 4 studies | 33% ± 12% | |
| club cell | 4 studies | 22% ± 3% | |
| classical monocyte | 3 studies | 20% ± 1% | |
| GABAergic neuron | 3 studies | 32% ± 8% | |
| glutamatergic neuron | 3 studies | 39% ± 10% | |
| dendritic cell | 3 studies | 23% ± 5% | |
| monocyte | 3 studies | 17% ± 2% | |
| macrophage | 3 studies | 20% ± 2% | |
| astrocyte | 3 studies | 23% ± 3% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| esophagus | 100% | 4180.50 | 1444 / 1445 | 100% | 43.42 | 183 / 183 |
| kidney | 100% | 5346.01 | 89 / 89 | 100% | 56.08 | 900 / 901 |
| stomach | 100% | 6113.23 | 359 / 359 | 100% | 73.21 | 285 / 286 |
| prostate | 100% | 3065.69 | 244 / 245 | 100% | 24.95 | 502 / 502 |
| ovary | 100% | 2808.39 | 180 / 180 | 100% | 31.06 | 428 / 430 |
| intestine | 100% | 7859.18 | 966 / 966 | 99% | 82.98 | 524 / 527 |
| lung | 100% | 6709.68 | 577 / 578 | 100% | 42.96 | 1150 / 1155 |
| uterus | 100% | 3244.32 | 170 / 170 | 99% | 33.37 | 456 / 459 |
| liver | 100% | 7867.93 | 226 / 226 | 99% | 55.04 | 403 / 406 |
| breast | 100% | 7847.75 | 459 / 459 | 99% | 30.46 | 1106 / 1118 |
| bladder | 100% | 2802.95 | 21 / 21 | 99% | 44.20 | 498 / 504 |
| skin | 99% | 4318.14 | 1785 / 1809 | 100% | 39.88 | 472 / 472 |
| thymus | 100% | 2581.32 | 651 / 653 | 98% | 18.19 | 591 / 605 |
| adrenal gland | 100% | 8576.57 | 258 / 258 | 97% | 52.98 | 223 / 230 |
| brain | 93% | 2090.92 | 2459 / 2642 | 100% | 24.08 | 702 / 705 |
| pancreas | 92% | 1629.53 | 302 / 328 | 99% | 34.53 | 176 / 178 |
| adipose | 100% | 8967.01 | 1204 / 1204 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 100% | 33.12 | 80 / 80 |
| muscle | 100% | 9241.04 | 803 / 803 | 0% | 0 | 0 / 0 |
| spleen | 100% | 2470.86 | 241 / 241 | 0% | 0 | 0 / 0 |
| tonsil | 0% | 0 | 0 / 0 | 100% | 35.35 | 45 / 45 |
| ureter | 0% | 0 | 0 / 0 | 100% | 12.56 | 1 / 1 |
| blood vessel | 100% | 3844.61 | 1331 / 1335 | 0% | 0 | 0 / 0 |
| heart | 97% | 5422.47 | 831 / 861 | 0% | 0 | 0 / 0 |
| peripheral blood | 74% | 1625.15 | 687 / 929 | 0% | 0 | 0 / 0 |
| lymph node | 0% | 0 | 0 / 0 | 59% | 7.89 | 17 / 29 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| GO_0019413 | Biological process | acetate biosynthetic process |
| GO_0045893 | Biological process | positive regulation of DNA-templated transcription |
| GO_0006085 | Biological process | acetyl-CoA biosynthetic process |
| GO_0008610 | Biological process | lipid biosynthetic process |
| GO_0019542 | Biological process | propionate biosynthetic process |
| GO_0019427 | Biological process | acetyl-CoA biosynthetic process from acetate |
| GO_0007616 | Biological process | long-term memory |
| GO_0005829 | Cellular component | cytosol |
| GO_0005759 | Cellular component | mitochondrial matrix |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0005634 | Cellular component | nucleus |
| GO_0003987 | Molecular function | acetate-CoA ligase activity |
| GO_0003713 | Molecular function | transcription coactivator activity |
| GO_0016208 | Molecular function | AMP binding |
| GO_0050218 | Molecular function | propionate-CoA ligase activity |
| GO_0005515 | Molecular function | protein binding |
| GO_0003682 | Molecular function | chromatin binding |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ACSS2 |
| Protein name | Acyl-CoA synthetase short chain family member 2 (cDNA FLJ53719, highly similar to Acetyl-coenzyme A synthetase, cytoplasmic (EC6.2.1.1)) Acetyl-coenzyme A synthetase (EC 6.2.1.1) Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17) acetate--CoA ligase (EC 6.2.1.1) Acyl-CoA synthetase short chain family member 2 |
| Synonyms | ACAS2 |
| Description | FUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids . Acetate is the preferred substrate . Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis . Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription . The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival . Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). . |
| Accessions | Q4G0E8 F8WCJ4 ENST00000493805.6 F8WC73 ENST00000253382.5 [Q9NR19-2] ENST00000475459.6 ENST00000488172.5 ENST00000484354.1 Q96FY7 Q9NR19 C9JXD9 Q6DKJ3 ENST00000480978.5 F8WBQ7 C9IYL0 ENST00000480274.1 ENST00000477932.5 F8WDJ9 ENST00000481284.5 C9J7L5 ENST00000360596.7 [Q9NR19-1] ENST00000473172.5 B4DEH9 C9JY31 |