ACSS2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0019413Biological processacetate biosynthetic process
GO_0045893Biological processpositive regulation of DNA-templated transcription
GO_0006085Biological processacetyl-CoA biosynthetic process
GO_0008610Biological processlipid biosynthetic process
GO_0019542Biological processpropionate biosynthetic process
GO_0019427Biological processacetyl-CoA biosynthetic process from acetate
GO_0007616Biological processlong-term memory
GO_0005829Cellular componentcytosol
GO_0005759Cellular componentmitochondrial matrix
GO_0005737Cellular componentcytoplasm
GO_0005634Cellular componentnucleus
GO_0003987Molecular functionacetate-CoA ligase activity
GO_0003713Molecular functiontranscription coactivator activity
GO_0016208Molecular functionAMP binding
GO_0050218Molecular functionpropionate-CoA ligase activity
GO_0005515Molecular functionprotein binding
GO_0003682Molecular functionchromatin binding
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACSS2
Protein nameAcyl-CoA synthetase short chain family member 2 (cDNA FLJ53719, highly similar to Acetyl-coenzyme A synthetase, cytoplasmic (EC6.2.1.1))
Acetyl-coenzyme A synthetase (EC 6.2.1.1)
Acetyl-coenzyme A synthetase, cytoplasmic (EC 6.2.1.1) (Acetate--CoA ligase) (Acetyl-CoA synthetase) (ACS) (AceCS) (Acetyl-CoA synthetase 1) (AceCS1) (Acyl-CoA synthetase short-chain family member 2) (Acyl-activating enzyme) (Propionate--CoA ligase) (EC 6.2.1.17)
acetate--CoA ligase (EC 6.2.1.1)
Acyl-CoA synthetase short chain family member 2
SynonymsACAS2
DescriptionFUNCTION: Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids . Acetate is the preferred substrate . Can also utilize propionate with a much lower affinity (By similarity). Nuclear ACSS2 promotes glucose deprivation-induced lysosomal biogenesis and autophagy, tumor cell survival and brain tumorigenesis . Glucose deprivation results in AMPK-mediated phosphorylation of ACSS2 leading to its translocation to the nucleus where it binds to TFEB and locally produces acetyl-CoA for histone acetylation in the promoter regions of TFEB target genes thereby activating their transcription . The regulation of genes associated with autophagy and lysosomal activity through ACSS2 is important for brain tumorigenesis and tumor survival . Acts as a chromatin-bound transcriptional coactivator that up-regulates histone acetylation and expression of neuronal genes (By similarity). Can be recruited to the loci of memory-related neuronal genes to maintain a local acetyl-CoA pool, providing the substrate for histone acetylation and promoting the expression of specific genes, which is essential for maintaining long-term spatial memory (By similarity). .

AccessionsQ4G0E8
F8WCJ4
ENST00000493805.6
F8WC73
ENST00000253382.5 [Q9NR19-2]
ENST00000475459.6
ENST00000488172.5
ENST00000484354.1
Q96FY7
Q9NR19
C9JXD9
Q6DKJ3
ENST00000480978.5
F8WBQ7
C9IYL0
ENST00000480274.1
ENST00000477932.5
F8WDJ9
ENST00000481284.5
C9J7L5
ENST00000360596.7 [Q9NR19-1]
ENST00000473172.5
B4DEH9
C9JY31