Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| astrocyte | 11 studies | 51% ± 18% | |
| retinal cone cell | 5 studies | 36% ± 13% | |
| retinal rod cell | 5 studies | 22% ± 3% | |
| GABAergic neuron | 4 studies | 61% ± 11% | |
| glutamatergic neuron | 4 studies | 54% ± 21% | |
| oligodendrocyte precursor cell | 4 studies | 36% ± 11% | |
| GABAergic interneuron | 3 studies | 30% ± 2% | |
| interneuron | 3 studies | 62% ± 16% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 5772.94 | 2597 / 2642 | 96% | 10.50 | 674 / 705 |
| adrenal gland | 48% | 392.01 | 125 / 258 | 76% | 3.96 | 175 / 230 |
| intestine | 5% | 32.61 | 48 / 966 | 40% | 2.12 | 210 / 527 |
| liver | 2% | 14.69 | 5 / 226 | 32% | 1.33 | 128 / 406 |
| stomach | 0% | 0 | 0 / 359 | 34% | 2.05 | 96 / 286 |
| peripheral blood | 22% | 210.71 | 205 / 929 | 0% | 0 | 0 / 0 |
| eye | 0% | 0 | 0 / 0 | 20% | 0.37 | 16 / 80 |
| muscle | 17% | 116.78 | 137 / 803 | 0% | 0 | 0 / 0 |
| bladder | 0% | 0 | 0 / 21 | 15% | 0.94 | 76 / 504 |
| spleen | 9% | 74.84 | 22 / 241 | 0% | 0 | 0 / 0 |
| breast | 0% | 0 | 0 / 459 | 7% | 0.21 | 83 / 1118 |
| lymph node | 0% | 0 | 0 / 0 | 7% | 0.10 | 2 / 29 |
| kidney | 1% | 5.73 | 1 / 89 | 4% | 0.11 | 38 / 901 |
| lung | 1% | 2.48 | 3 / 578 | 4% | 0.08 | 48 / 1155 |
| pancreas | 0% | 2.37 | 1 / 328 | 4% | 0.17 | 7 / 178 |
| esophagus | 1% | 3.98 | 10 / 1445 | 3% | 0.08 | 6 / 183 |
| skin | 0% | 0.25 | 1 / 1809 | 3% | 0.04 | 12 / 472 |
| prostate | 2% | 29.98 | 4 / 245 | 1% | 0.01 | 3 / 502 |
| tonsil | 0% | 0 | 0 / 0 | 2% | 0.36 | 1 / 45 |
| thymus | 1% | 3.45 | 4 / 653 | 1% | 0.02 | 8 / 605 |
| ovary | 0% | 0 | 0 / 180 | 2% | 0.04 | 7 / 430 |
| uterus | 0% | 0 | 0 / 170 | 1% | 0.03 | 6 / 459 |
| heart | 1% | 4.84 | 7 / 861 | 0% | 0 | 0 / 0 |
| blood vessel | 0% | 0.99 | 2 / 1335 | 0% | 0 | 0 / 0 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| adipose | 0% | 0 | 0 / 1204 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0001676 | Biological process | long-chain fatty acid metabolic process |
| GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
| GO_0006637 | Biological process | acyl-CoA metabolic process |
| GO_0035338 | Biological process | long-chain fatty-acyl-CoA biosynthetic process |
| GO_0007405 | Biological process | neuroblast proliferation |
| GO_0005778 | Cellular component | peroxisomal membrane |
| GO_0005741 | Cellular component | mitochondrial outer membrane |
| GO_0005783 | Cellular component | endoplasmic reticulum |
| GO_0016020 | Cellular component | membrane |
| GO_0005886 | Cellular component | plasma membrane |
| GO_0005789 | Cellular component | endoplasmic reticulum membrane |
| GO_0047676 | Molecular function | arachidonate-CoA ligase activity |
| GO_0004467 | Molecular function | long-chain fatty acid-CoA ligase activity |
| GO_0042803 | Molecular function | protein homodimerization activity |
| GO_0005524 | Molecular function | ATP binding |
| Gene name | ACSL6 |
| Protein name | long-chain-fatty-acid--CoA ligase (EC 6.2.1.3) Arachidonate--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) Acyl-CoA synthetase long chain family member 6 Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase) Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6) |
| Synonyms | FACL6 LACS5 KIAA0837 ACS2 |
| Description | FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation . Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. . FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. . FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. . FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. . FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. . FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. . |
| Accessions | C9J8C7 A0A499FJL5 ENST00000441995.2 ENST00000651454.1 ENST00000419502.5 ENST00000296869.9 Q9UKU0 ENST00000651356.1 [Q9UKU0-8] ENST00000357096.5 [Q9UKU0-7] ENST00000379240.5 [Q9UKU0-4] A0A494C0A5 A0A494C1I9 A0A494C0J9 A0A494C0D5 C9J3Z0 ENST00000379255.5 [Q9UKU0-7] C9JPA5 ENST00000652424.1 ENST00000651883.2 [Q9UKU0-1] ENST00000652493.1 ENST00000651086.1 A0A494C0B6 A0A494C0V0 ENST00000651427.1 ENST00000651250.1 ENST00000379244.5 [Q9UKU0-3] ENST00000543479.5 [Q9UKU0-6] ENST00000650912.1 C9J4I1 ENST00000651269.1 C9JT10 A0A494BZW8 ENST00000431707.5 ENST00000430403.5 A0A494C005 ENST00000414078.5 C9JK59 ENST00000379246.5 [Q9UKU0-9] ENST00000416557.5 E7ERD7 A0A494C046 ENST00000434099.6 ENST00000650697.1 |
