ACSL6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0001676Biological processlong-chain fatty acid metabolic process
GO_0000038Biological processvery long-chain fatty acid metabolic process
GO_0006637Biological processacyl-CoA metabolic process
GO_0035338Biological processlong-chain fatty-acyl-CoA biosynthetic process
GO_0007405Biological processneuroblast proliferation
GO_0005778Cellular componentperoxisomal membrane
GO_0005741Cellular componentmitochondrial outer membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0016020Cellular componentmembrane
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0047676Molecular functionarachidonate-CoA ligase activity
GO_0004467Molecular functionlong-chain fatty acid-CoA ligase activity
GO_0042803Molecular functionprotein homodimerization activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameACSL6
Protein namelong-chain-fatty-acid--CoA ligase (EC 6.2.1.3)
Arachidonate--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3)
Acyl-CoA synthetase long chain family member 6
Long-chain-fatty-acid--CoA ligase (EC 6.2.1.15) (EC 6.2.1.3) (Acyl-CoA synthetase) (Long-chain acyl-CoA synthetase)
Long-chain-fatty-acid--CoA ligase 6 (EC 6.2.1.3) (Arachidonate--CoA ligase) (EC 6.2.1.15) (Long-chain acyl-CoA synthetase 6) (LACS 6)
SynonymsFACL6
LACS5
KIAA0837
ACS2
DescriptionFUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation . Plays an important role in fatty acid metabolism in brain and the acyl-CoAs produced may be utilized exclusively for the synthesis of the brain lipid. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

FUNCTION: Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoAs for both synthesis of cellular lipids, and degradation via beta-oxidation. .

AccessionsC9J8C7
A0A499FJL5
ENST00000441995.2
ENST00000651454.1
ENST00000419502.5
ENST00000296869.9
Q9UKU0
ENST00000651356.1 [Q9UKU0-8]
ENST00000357096.5 [Q9UKU0-7]
ENST00000379240.5 [Q9UKU0-4]
A0A494C0A5
A0A494C1I9
A0A494C0J9
A0A494C0D5
C9J3Z0
ENST00000379255.5 [Q9UKU0-7]
C9JPA5
ENST00000652424.1
ENST00000651883.2 [Q9UKU0-1]
ENST00000652493.1
ENST00000651086.1
A0A494C0B6
A0A494C0V0
ENST00000651427.1
ENST00000651250.1
ENST00000379244.5 [Q9UKU0-3]
ENST00000543479.5 [Q9UKU0-6]
ENST00000650912.1
C9J4I1
ENST00000651269.1
C9JT10
A0A494BZW8
ENST00000431707.5
ENST00000430403.5
A0A494C005
ENST00000414078.5
C9JK59
ENST00000379246.5 [Q9UKU0-9]
ENST00000416557.5
E7ERD7
A0A494C046
ENST00000434099.6
ENST00000650697.1