ACER2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060049Biological processregulation of protein glycosylation
GO_0006919Biological processactivation of cysteine-type endopeptidase activity involved in apoptotic process
GO_0071466Biological processcellular response to xenobiotic stimulus
GO_0006974Biological processDNA damage response
GO_0001953Biological processnegative regulation of cell-matrix adhesion
GO_0033629Biological processnegative regulation of cell adhesion mediated by integrin
GO_0046514Biological processceramide catabolic process
GO_0030149Biological processsphingolipid catabolic process
GO_0042981Biological processregulation of apoptotic process
GO_0010506Biological processregulation of autophagy
GO_0046512Biological processsphingosine biosynthetic process
GO_0032526Biological processresponse to retinoic acid
GO_0008284Biological processpositive regulation of cell population proliferation
GO_0030330Biological processDNA damage response, signal transduction by p53 class mediator
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0017040Molecular functionN-acylsphingosine amidohydrolase activity
GO_0102121Molecular functionceramidase activity
GO_0046872Molecular functionmetal ion binding
GO_0071633Molecular functiondihydroceramidase activity

IV. Literature review

[source]
Gene nameACER2
Protein nameAlkaline ceramidase 2 (AlkCDase 2) (Alkaline CDase 2) (haCER2) (EC 3.5.1.-) (EC 3.5.1.23) (Acylsphingosine deacylase 3-like) (N-acylsphingosine amidohydrolase 3-like)
SynonymsPP11646
ASAH3L
DescriptionFUNCTION: Golgi ceramidase that catalyzes the hydrolysis of ceramides into sphingoid bases like sphingosine and free fatty acids at alkaline pH . Ceramides, sphingosine, and its phosphorylated form sphingosine-1-phosphate are bioactive lipids that mediate cellular signaling pathways regulating several biological processes including cell proliferation, apoptosis and differentiation . Has a better catalytic efficiency towards unsaturated long-chain ceramides, including C18:1-, C20:1- and C24:1-ceramides . Saturated long-chain ceramides and unsaturated very long-chain ceramides are also good substrates, whereas saturated very long-chain ceramides and short-chain ceramides are poor substrates . Also hydrolyzes dihydroceramides to produce dihydrosphingosine . It is the ceramidase that controls the levels of circulating sphingosine-1-phosphate and dihydrosphingosine-1-phosphate in plasma through their production by hematopoietic cells (By similarity). Regulates cell proliferation, autophagy and apoptosis by the production of sphingosine and sphingosine-1-phosphate . As part of a p53/TP53-dependent pathway, promotes for instance autophagy and apoptosis in response to DNA damage . Through the production of sphingosine, may also regulate the function of the Golgi complex and regulate the glycosylation of proteins . .

AccessionsQ5QJU3
ENST00000340967.3 [Q5QJU3-1]