Name | Number of supported studies | Average coverage | |
---|---|---|---|
ciliated cell | 12 studies | 26% ± 9% | |
endothelial cell | 11 studies | 31% ± 11% | |
astrocyte | 10 studies | 31% ± 15% | |
oligodendrocyte | 10 studies | 26% ± 9% | |
epithelial cell | 7 studies | 34% ± 13% | |
oligodendrocyte precursor cell | 7 studies | 30% ± 13% | |
club cell | 6 studies | 22% ± 7% | |
Mueller cell | 6 studies | 21% ± 5% | |
type II pneumocyte | 6 studies | 29% ± 8% | |
fibroblast | 5 studies | 27% ± 10% | |
type I pneumocyte | 5 studies | 22% ± 5% | |
goblet cell | 5 studies | 23% ± 12% | |
respiratory goblet cell | 4 studies | 20% ± 2% | |
basal cell | 4 studies | 35% ± 17% | |
retinal pigment epithelial cell | 4 studies | 31% ± 7% | |
adipocyte | 4 studies | 19% ± 2% | |
cardiac muscle cell | 4 studies | 23% ± 2% | |
hepatocyte | 4 studies | 66% ± 12% | |
macrophage | 4 studies | 18% ± 2% | |
glutamatergic neuron | 4 studies | 45% ± 17% | |
neuron | 4 studies | 39% ± 22% | |
secretory cell | 3 studies | 23% ± 3% | |
glial cell | 3 studies | 25% ± 7% | |
microglial cell | 3 studies | 20% ± 1% | |
GABAergic neuron | 3 studies | 52% ± 3% | |
enteroendocrine cell | 3 studies | 20% ± 5% | |
interneuron | 3 studies | 45% ± 20% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
brain | 100% | 2375.66 | 2640 / 2642 | 100% | 38.22 | 705 / 705 |
intestine | 100% | 3933.03 | 966 / 966 | 100% | 27.81 | 525 / 527 |
liver | 100% | 6334.92 | 226 / 226 | 100% | 36.30 | 404 / 406 |
breast | 100% | 3174.31 | 459 / 459 | 99% | 57.36 | 1112 / 1118 |
esophagus | 100% | 3034.10 | 1445 / 1445 | 99% | 26.41 | 182 / 183 |
bladder | 100% | 2829.24 | 21 / 21 | 99% | 35.83 | 501 / 504 |
lung | 100% | 2842.66 | 576 / 578 | 100% | 26.31 | 1152 / 1155 |
stomach | 100% | 3590.03 | 359 / 359 | 99% | 28.51 | 284 / 286 |
prostate | 100% | 2662.61 | 245 / 245 | 99% | 22.44 | 497 / 502 |
thymus | 100% | 2792.92 | 653 / 653 | 99% | 30.77 | 596 / 605 |
uterus | 100% | 2488.64 | 170 / 170 | 98% | 24.50 | 452 / 459 |
kidney | 100% | 3406.73 | 89 / 89 | 98% | 29.01 | 887 / 901 |
pancreas | 100% | 2570.61 | 328 / 328 | 98% | 25.55 | 175 / 178 |
ovary | 100% | 2015.45 | 180 / 180 | 96% | 13.78 | 412 / 430 |
skin | 100% | 3833.87 | 1809 / 1809 | 92% | 24.58 | 436 / 472 |
adrenal gland | 100% | 3270.45 | 258 / 258 | 90% | 12.93 | 207 / 230 |
spleen | 100% | 1719.88 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 13.88 | 1 / 1 |
blood vessel | 100% | 2640.63 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 2364.49 | 1203 / 1204 | 0% | 0 | 0 / 0 |
muscle | 100% | 2161.49 | 801 / 803 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 98% | 21.69 | 44 / 45 |
heart | 97% | 3023.77 | 838 / 861 | 0% | 0 | 0 / 0 |
lymph node | 0% | 0 | 0 / 0 | 72% | 10.05 | 21 / 29 |
eye | 0% | 0 | 0 / 0 | 56% | 8.36 | 45 / 80 |
peripheral blood | 43% | 686.41 | 402 / 929 | 0% | 0 | 0 / 0 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0015910 | Biological process | long-chain fatty acid import into peroxisome |
GO_0042760 | Biological process | very long-chain fatty acid catabolic process |
GO_0014070 | Biological process | response to organic cyclic compound |
GO_0000038 | Biological process | very long-chain fatty acid metabolic process |
GO_0015721 | Biological process | bile acid and bile salt transport |
GO_0006633 | Biological process | fatty acid biosynthetic process |
GO_0007031 | Biological process | peroxisome organization |
GO_1903512 | Biological process | phytanic acid metabolic process |
GO_0006699 | Biological process | bile acid biosynthetic process |
GO_0006635 | Biological process | fatty acid beta-oxidation |
GO_0009410 | Biological process | response to xenobiotic stimulus |
GO_0005778 | Cellular component | peroxisomal membrane |
GO_0016020 | Cellular component | membrane |
GO_0005739 | Cellular component | mitochondrion |
GO_0005777 | Cellular component | peroxisome |
GO_0005829 | Cellular component | cytosol |
GO_0005782 | Cellular component | peroxisomal matrix |
GO_0043231 | Cellular component | intracellular membrane-bounded organelle |
GO_0042803 | Molecular function | protein homodimerization activity |
GO_0005324 | Molecular function | long-chain fatty acid transmembrane transporter activity |
GO_0140359 | Molecular function | ABC-type transporter activity |
GO_0005524 | Molecular function | ATP binding |
GO_0047617 | Molecular function | fatty acyl-CoA hydrolase activity |
GO_0042626 | Molecular function | ATPase-coupled transmembrane transporter activity |
GO_0005515 | Molecular function | protein binding |
GO_0016887 | Molecular function | ATP hydrolysis activity |
Gene name | ABCD3 |
Protein name | ATP binding cassette subfamily D member 3 ATP-binding cassette sub-family D member 3 (EC 3.1.2.-) (EC 7.6.2.-) (70 kDa peroxisomal membrane protein) (PMP70) |
Synonyms | PMP70 PXMP1 |
Description | FUNCTION: Broad substrate specificity ATP-dependent transporter of the ATP-binding cassette (ABC) family that catalyzes the transport of long-chain fatty acids (LCFA)-CoA, dicarboxylic acids-CoA, long-branched-chain fatty acids-CoA and bile acids from the cytosol to the peroxisome lumen for beta-oxydation . Has fatty acyl-CoA thioesterase and ATPase activities . Probably hydrolyzes fatty acyl-CoAs into free fatty acids prior to their ATP-dependent transport into peroxisomes (By similarity). Thus, play a role in regulation of LCFAs and energy metabolism namely, in the degradation and biosynthesis of fatty acids by beta-oxidation . . |
Accessions | P28288 A0A3B3ITW3 ENST00000315713.5 [P28288-3] ENST00000370214.9 [P28288-1] ENST00000647998.2 |