ABCC4 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0060271Biological processcilium assembly
GO_0032310Biological processprostaglandin secretion
GO_0006805Biological processxenobiotic metabolic process
GO_0006855Biological processxenobiotic transmembrane transport
GO_0034775Biological processglutathione transmembrane transport
GO_0098656Biological processmonoatomic anion transmembrane transport
GO_0055085Biological processtransmembrane transport
GO_0150104Biological processtransport across blood-brain barrier
GO_0002576Biological processplatelet degranulation
GO_0015747Biological processurate transport
GO_0140115Biological processexport across plasma membrane
GO_0015721Biological processbile acid and bile salt transport
GO_0070730Biological processcAMP transport
GO_0015732Biological processprostaglandin transport
GO_1903790Biological processguanine nucleotide transmembrane transport
GO_0071716Biological processleukotriene transport
GO_0016324Cellular componentapical plasma membrane
GO_0005730Cellular componentnucleolus
GO_0005886Cellular componentplasma membrane
GO_0016020Cellular componentmembrane
GO_0031088Cellular componentplatelet dense granule membrane
GO_0005794Cellular componentGolgi apparatus
GO_0098591Cellular componentexternal side of apical plasma membrane
GO_0016323Cellular componentbasolateral plasma membrane
GO_0140359Molecular functionABC-type transporter activity
GO_0015562Molecular functionefflux transmembrane transporter activity
GO_0043225Molecular functionATPase-coupled inorganic anion transmembrane transporter activity
GO_0015143Molecular functionurate transmembrane transporter activity
GO_0015432Molecular functionABC-type bile acid transporter activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0015431Molecular functionABC-type glutathione S-conjugate transporter activity
GO_0015216Molecular functionpurine nucleotide transmembrane transporter activity
GO_0001409Molecular functionguanine nucleotide transmembrane transporter activity
GO_0042910Molecular functionxenobiotic transmembrane transporter activity
GO_0034634Molecular functionglutathione transmembrane transporter activity
GO_0005524Molecular functionATP binding
GO_0016404Molecular function15-hydroxyprostaglandin dehydrogenase (NAD+) activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0015132Molecular functionprostaglandin transmembrane transporter activity
GO_0005515Molecular functionprotein binding
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCC4
Protein nameATP binding cassette subfamily C member 4
ATP-binding cassette subfamily C member 4 variant 1 (ATP-binding cassette subfamily C member 4 variant 3) (ATP-binding cassette, sub-family C (CFTR/MRP), member 4, isoform CRA_a)
Multidrug resistance-associated protein 4 isoform 1
ATP-binding cassette sub-family C member 4 (EC 7.6.2.-) (EC 7.6.2.2) (EC 7.6.2.3) (MRP/cMOAT-related ABC transporter) (Multi-specific organic anion transporter B) (MOAT-B) (Multidrug resistance-associated protein 4)
ATP binding cassette subfamily C member 4 (ATP-binding cassette subfamily C member 4 variant 2) (ATP-binding cassette, sub-family C (CFTR/MRP), member 4, isoform CRA_d)
SynonymshCG_2039665
MRP4
MOATB
DescriptionFUNCTION: ATP-dependent transporter of the ATP-binding cassette (ABC) family that actively extrudes physiological compounds and xenobiotics from cells. Transports a range of endogenous molecules that have a key role in cellular communication and signaling, including cyclic nucleotides such as cyclic AMP (cAMP) and cyclic GMP (cGMP), bile acids, steroid conjugates, urate, and prostaglandins . Mediates the ATP-dependent efflux of glutathione conjugates such as leukotriene C4 (LTC4) and leukotriene B4 (LTB4) too. The presence of GSH is necessary for the ATP-dependent transport of LTB4, whereas GSH is not required for the transport of LTC4 . Mediates the cotransport of bile acids with reduced glutathione (GSH) . Transports a wide range of drugs and their metabolites, including anticancer, antiviral and antibiotics molecules . Confers resistance to anticancer agents such as methotrexate . .

AccessionsENST00000646439.1 [O15439-2]
ENST00000643051.1
ENST00000536256.3 [O15439-4]
ENST00000642524.1
A0A2R8Y6V8
Q8IWU1
ENST00000643842.1
O15439
Q8IUA3
A0A2R8YDC1
A0A2R8YDG7
ENST00000645532.1
A0A5C0NTB8
ENST00000645237.2 [O15439-1]
A0A2R8Y5Z3
ENST00000629385.1 [O15439-3]
ENST00000643556.1