ABCA3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070925Biological processorganelle assembly
GO_0055091Biological processphospholipid homeostasis
GO_0030324Biological processlung development
GO_0006855Biological processxenobiotic transmembrane transport
GO_0015914Biological processphospholipid transport
GO_0032464Biological processpositive regulation of protein homooligomerization
GO_0120009Biological processintermembrane lipid transfer
GO_0150172Biological processregulation of phosphatidylcholine metabolic process
GO_0046890Biological processregulation of lipid biosynthetic process
GO_0006869Biological processlipid transport
GO_0042908Biological processxenobiotic transport
GO_2001140Biological processpositive regulation of phospholipid transport
GO_0051384Biological processresponse to glucocorticoid
GO_1902995Biological processpositive regulation of phospholipid efflux
GO_0010875Biological processpositive regulation of cholesterol efflux
GO_0043129Biological processsurfactant homeostasis
GO_0046470Biological processphosphatidylcholine metabolic process
GO_0019538Biological processprotein metabolic process
GO_0034204Biological processlipid translocation
GO_0046618Biological processxenobiotic export from cell
GO_0009410Biological processresponse to xenobiotic stimulus
GO_0046471Biological processphosphatidylglycerol metabolic process
GO_0005615Cellular componentextracellular space
GO_0005886Cellular componentplasma membrane
GO_0042599Cellular componentlamellar body
GO_0097208Cellular componentalveolar lamellar body
GO_0097232Cellular componentlamellar body membrane
GO_0005770Cellular componentlate endosome
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0097233Cellular componentalveolar lamellar body membrane
GO_0032585Cellular componentmultivesicular body membrane
GO_0030659Cellular componentcytoplasmic vesicle membrane
GO_0005765Cellular componentlysosomal membrane
GO_0140345Molecular functionphosphatidylcholine flippase activity
GO_0008559Molecular functionABC-type xenobiotic transporter activity
GO_0005524Molecular functionATP binding
GO_0005319Molecular functionlipid transporter activity
GO_0042626Molecular functionATPase-coupled transmembrane transporter activity
GO_0120019Molecular functionphosphatidylcholine transfer activity
GO_0016887Molecular functionATP hydrolysis activity

IV. Literature review

[source]
Gene nameABCA3
Protein nameABCA3 variant protein
Phospholipid-transporting ATPase ABCA3 (EC 7.6.2.1) (ABC-C transporter) (ATP-binding cassette sub-family A member 3) (ATP-binding cassette transporter 3) (ATP-binding cassette 3) (Xenobiotic-transporting ATPase ABCA3) (EC 7.6.2.2) [Cleaved into: 150 Kda mature form]
ATP-binding cassette, sub-family A (ABC1), member 3
ATP binding cassette subfamily A member 3
SynonymsABC3
protein
variant
DescriptionFUNCTION: Catalyzes the ATP-dependent transport of phospholipids such as phosphatidylcholine and phosphoglycerol from the cytoplasm into the lumen side of lamellar bodies, in turn participates in the lamellar bodies biogenesis and homeostasis of pulmonary surfactant . Transports preferentially phosphatidylcholine containing short acyl chains . In addition plays a role as an efflux transporter of miltefosine across macrophage membranes and free cholesterol (FC) through intralumenal vesicles by removing FC from the cell as a component of surfactant and protects cells from free cholesterol toxicity . .

AccessionsQ99758
Q4LE27
H0Y3H2
ENST00000567910.1 [Q99758-2]
ENST00000301732.10 [Q99758-1]
A7MBM9
ENST00000382381.7