I. Expression across cell types
Name | Number of supported studies  | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 3 studies | 60% ± 16% | |
| OFF-bipolar cell | 3 studies | 25% ± 10% | |
| ON-bipolar cell | 3 studies | 32% ± 11% | |
| rod bipolar cell | 3 studies | 71% ± 17% |
Name | Number of supported studies | Average coverage | |
|---|---|---|---|
| retinal bipolar neuron | 3 studies | 60% ± 16% | |
| OFF-bipolar cell | 3 studies | 25% ± 10% | |
| ON-bipolar cell | 3 studies | 32% ± 11% | |
| rod bipolar cell | 3 studies | 71% ± 17% |
Insufficient scRNA-seq data for expression of AANAT at tissue level.
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
|---|---|---|---|---|---|---|
| brain | 98% | 36.62 | 2583 / 2642 | 49% | 1.02 | 342 / 705 |
| ovary | 89% | 11.59 | 160 / 180 | 19% | 0.30 | 83 / 430 |
| lung | 94% | 25.58 | 546 / 578 | 12% | 0.22 | 144 / 1155 |
| kidney | 93% | 17.25 | 83 / 89 | 11% | 0.18 | 96 / 901 |
| thymus | 99% | 28.58 | 647 / 653 | 3% | 0.04 | 16 / 605 |
| spleen | 100% | 65.33 | 241 / 241 | 0% | 0 | 0 / 0 |
| peripheral blood | 95% | 32.71 | 883 / 929 | 0% | 0 | 0 / 0 |
| adrenal gland | 95% | 22.34 | 244 / 258 | 0% | 0.06 | 1 / 230 |
| pancreas | 77% | 9.38 | 251 / 328 | 14% | 0.26 | 25 / 178 |
| intestine | 80% | 18.95 | 775 / 966 | 8% | 0.13 | 40 / 527 |
| prostate | 88% | 15.18 | 215 / 245 | 0% | 0 | 0 / 502 |
| esophagus | 66% | 10.55 | 955 / 1445 | 21% | 0.41 | 39 / 183 |
| skin | 76% | 15.04 | 1382 / 1809 | 10% | 0.17 | 45 / 472 |
| stomach | 81% | 10.61 | 292 / 359 | 4% | 0.06 | 11 / 286 |
| uterus | 70% | 9.43 | 119 / 170 | 14% | 0.26 | 62 / 459 |
| bladder | 67% | 9.14 | 14 / 21 | 10% | 0.18 | 48 / 504 |
| breast | 68% | 8.74 | 311 / 459 | 3% | 0.05 | 33 / 1118 |
| adipose | 71% | 12.84 | 849 / 1204 | 0% | 0 | 0 / 0 |
| blood vessel | 56% | 8.65 | 750 / 1335 | 0% | 0 | 0 / 0 |
| heart | 55% | 6.07 | 473 / 861 | 0% | 0 | 0 / 0 |
| muscle | 34% | 3.13 | 276 / 803 | 0% | 0 | 0 / 0 |
| liver | 26% | 2.60 | 59 / 226 | 4% | 0.10 | 18 / 406 |
| lymph node | 0% | 0 | 0 / 0 | 28% | 1.07 | 8 / 29 |
| tonsil | 0% | 0 | 0 / 0 | 16% | 0.22 | 7 / 45 |
| eye | 0% | 0 | 0 / 0 | 5% | 0.39 | 4 / 80 |
| abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
| ureter | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 1 |
| GO_0046219 | Biological process | indolalkylamine biosynthetic process |
| GO_1901652 | Biological process | response to peptide |
| GO_0034097 | Biological process | response to cytokine |
| GO_0032868 | Biological process | response to insulin |
| GO_0030187 | Biological process | melatonin biosynthetic process |
| GO_0006474 | Biological process | N-terminal protein amino acid acetylation |
| GO_0007623 | Biological process | circadian rhythm |
| GO_0071320 | Biological process | cellular response to cAMP |
| GO_0009648 | Biological process | photoperiodism |
| GO_0010043 | Biological process | response to zinc ion |
| GO_0034695 | Biological process | response to prostaglandin E |
| GO_0009416 | Biological process | response to light stimulus |
| GO_0046688 | Biological process | response to copper ion |
| GO_0051412 | Biological process | response to corticosterone |
| GO_0051592 | Biological process | response to calcium ion |
| GO_0048471 | Cellular component | perinuclear region of cytoplasm |
| GO_0005829 | Cellular component | cytosol |
| GO_0005737 | Cellular component | cytoplasm |
| GO_0071889 | Molecular function | 14-3-3 protein binding |
| GO_0004059 | Molecular function | aralkylamine N-acetyltransferase activity |
| GO_0004060 | Molecular function | arylamine N-acetyltransferase activity |
| GO_0005515 | Molecular function | protein binding |
| Gene name | AANAT |
| Protein name | Aralkylamine N-acetyltransferase Arylalkylamine N-acetyltransferase Serotonin N-acetyltransferase (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) Serotonin N-acetyltransferase (Serotonin acetylase) (EC 2.3.1.87) (Aralkylamine N-acetyltransferase) (AA-NAT) |
| Synonyms | hCG_30892 SNAT |
| Description | FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. . FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. . FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. . FUNCTION: Controls the night/day rhythm of melatonin production in the pineal gland. Catalyzes the N-acetylation of serotonin into N-acetylserotonin, the penultimate step in the synthesis of melatonin. . |
| Accessions | Q9H3T0 ENST00000250615.7 [Q16613-2] ENST00000392492.8 [Q16613-1] Q9GZS4 Q9H3T1 ENST00000587798.1 Q16613 Q9H3S9 K7ESH7 F1T0I5 K7ERF6 ENST00000585649.1 |
