ZRSR2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0000398Biological processmRNA splicing, via spliceosome
GO_0000245Biological processspliceosomal complex assembly
GO_0008380Biological processRNA splicing
GO_0089701Cellular componentU2AF complex
GO_0005654Cellular componentnucleoplasm
GO_0005681Cellular componentspliceosomal complex
GO_0005689Cellular componentU12-type spliceosomal complex
GO_0030628Molecular functionpre-mRNA 3'-splice site binding
GO_0042802Molecular functionidentical protein binding
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZRSR2
Protein nameU2 small nuclear ribonucleoprotein auxiliary factor 35 kDa subunit-related protein 2 (CCCH type zinc finger, RNA-binding motif and serine/arginine rich protein 2) (Renal carcinoma antigen NY-REN-20) (U2(RNU2) small nuclear RNA auxiliary factor 1-like 2) (U2AF35-related protein) (URP)
Zinc finger CCCH-type, RNA binding motif and serine/arginine rich 2
Zinc finger (CCCH type), RNA-binding motif and serine/arginine rich 2
SynonymsU2AF1RS2
U2AF1L2
URP
U2AF1-RS2
DescriptionFUNCTION: Pre-mRNA-binding protein required for splicing of both U2- and U12-type introns. Selectively interacts with the 3'-splice site of U2- and U12-type pre-mRNAs and promotes different steps in U2 and U12 intron splicing. Recruited to U12 pre-mRNAs in an ATP-dependent manner and is required for assembly of the prespliceosome, a precursor to other spliceosomal complexes. For U2-type introns, it is selectively and specifically required for the second step of splicing. .

AccessionsENST00000684799.1
A0A8I5QKS0
ENST00000690252.1
A6NDW0
ENST00000691502.1
Q86VN0
ENST00000380308.7
A0A8I5KSD0
A0A8I5KRH1
Q15696
ENST00000307771.8