Name | Number of supported studies | Average coverage | |
---|---|---|---|
astrocyte | 10 studies | 34% ± 19% | |
oligodendrocyte | 10 studies | 29% ± 15% | |
glutamatergic neuron | 9 studies | 47% ± 25% | |
adipocyte | 9 studies | 25% ± 7% | |
endothelial cell | 7 studies | 28% ± 10% | |
GABAergic neuron | 7 studies | 40% ± 22% | |
oligodendrocyte precursor cell | 6 studies | 22% ± 6% | |
fibroblast | 6 studies | 31% ± 19% | |
interneuron | 5 studies | 45% ± 25% | |
neuron | 4 studies | 41% ± 19% | |
microglial cell | 4 studies | 32% ± 18% | |
retinal cone cell | 4 studies | 25% ± 6% | |
retinal rod cell | 4 studies | 22% ± 7% | |
pericyte | 4 studies | 26% ± 10% | |
smooth muscle cell | 4 studies | 30% ± 21% | |
GABAergic interneuron | 3 studies | 19% ± 3% | |
cardiac muscle cell | 3 studies | 19% ± 2% | |
Mueller cell | 3 studies | 18% ± 2% | |
retina horizontal cell | 3 studies | 19% ± 3% | |
endothelial cell of vascular tree | 3 studies | 25% ± 8% | |
macrophage | 3 studies | 23% ± 5% | |
hepatocyte | 3 studies | 28% ± 10% | |
neural progenitor cell | 3 studies | 22% ± 5% |
Tissue | GTEx Coverage | GTEx Average TPM | GTEx Number of samples | TCGA Coverage | TCGA Average TPM | TCGA Number of samples |
---|---|---|---|---|---|---|
prostate | 100% | 266.42 | 245 / 245 | 97% | 2.65 | 485 / 502 |
breast | 100% | 230.61 | 459 / 459 | 96% | 2.86 | 1072 / 1118 |
brain | 99% | 221.92 | 2623 / 2642 | 96% | 2.17 | 679 / 705 |
ovary | 100% | 376.08 | 180 / 180 | 95% | 2.64 | 407 / 430 |
esophagus | 100% | 175.95 | 1443 / 1445 | 93% | 2.84 | 171 / 183 |
thymus | 100% | 296.06 | 653 / 653 | 92% | 2.20 | 555 / 605 |
uterus | 100% | 270.37 | 170 / 170 | 90% | 2.40 | 415 / 459 |
lung | 100% | 187.48 | 576 / 578 | 90% | 1.99 | 1037 / 1155 |
stomach | 100% | 154.84 | 358 / 359 | 87% | 2.07 | 250 / 286 |
intestine | 100% | 196.66 | 966 / 966 | 87% | 1.98 | 459 / 527 |
bladder | 100% | 220.43 | 21 / 21 | 83% | 1.80 | 418 / 504 |
adrenal gland | 100% | 345.65 | 258 / 258 | 80% | 1.69 | 185 / 230 |
pancreas | 100% | 215.89 | 327 / 328 | 80% | 1.35 | 143 / 178 |
skin | 100% | 291.40 | 1806 / 1809 | 77% | 1.87 | 362 / 472 |
kidney | 100% | 173.42 | 89 / 89 | 73% | 1.46 | 654 / 901 |
liver | 100% | 184.30 | 226 / 226 | 67% | 1.16 | 270 / 406 |
lymph node | 0% | 0 | 0 / 0 | 100% | 2.28 | 29 / 29 |
muscle | 100% | 293.83 | 803 / 803 | 0% | 0 | 0 / 0 |
spleen | 100% | 231.15 | 241 / 241 | 0% | 0 | 0 / 0 |
ureter | 0% | 0 | 0 / 0 | 100% | 1.08 | 1 / 1 |
blood vessel | 100% | 235.74 | 1334 / 1335 | 0% | 0 | 0 / 0 |
adipose | 100% | 219.68 | 1203 / 1204 | 0% | 0 | 0 / 0 |
heart | 93% | 133.86 | 805 / 861 | 0% | 0 | 0 / 0 |
tonsil | 0% | 0 | 0 / 0 | 89% | 1.99 | 40 / 45 |
peripheral blood | 65% | 158.55 | 603 / 929 | 0% | 0 | 0 / 0 |
eye | 0% | 0 | 0 / 0 | 56% | 1.13 | 45 / 80 |
abdomen | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
bone marrow | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
diaphragm | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
gingiva | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasal cavity | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nasopharynx | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
nose | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
placenta | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
spinal column | 0% | 0 | 0 / 0 | 0% | 0 | 0 / 0 |
GO_0006974 | Biological process | DNA damage response |
GO_0071932 | Biological process | replication fork reversal |
GO_0031297 | Biological process | replication fork processing |
GO_0009411 | Biological process | response to UV |
GO_0006281 | Biological process | DNA repair |
GO_0036292 | Biological process | DNA rewinding |
GO_0006338 | Biological process | chromatin remodeling |
GO_0045910 | Biological process | negative regulation of DNA recombination |
GO_0043596 | Cellular component | nuclear replication fork |
GO_0005654 | Cellular component | nucleoplasm |
GO_0140658 | Molecular function | ATP-dependent chromatin remodeler activity |
GO_0003678 | Molecular function | DNA helicase activity |
GO_0070530 | Molecular function | K63-linked polyubiquitin modification-dependent protein binding |
GO_0005515 | Molecular function | protein binding |
GO_0008270 | Molecular function | zinc ion binding |
GO_0036310 | Molecular function | ATP-dependent DNA/DNA annealing activity |
GO_0004520 | Molecular function | DNA endonuclease activity |
GO_0005524 | Molecular function | ATP binding |
Gene name | ZRANB3 |
Protein name | Zinc finger RANBP2-type containing 3 DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)] Zinc finger RANBP2-type containing 3 (Zinc finger, RAN-binding domain containing 3, isoform CRA_g) |
Synonyms | hCG_1643600 |
Description | FUNCTION: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events . Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase . In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks . . |
Accessions | ENST00000264159.11 [Q5FWF4-1] F5GYN7 ENST00000401392.5 [Q5FWF4-3] ENST00000536680.5 Q5FWF4 ENST00000403017.2 F8WCT9 ENST00000619650.4 [Q5FWF4-2] |