ZRANB3 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0006974Biological processDNA damage response
GO_0071932Biological processreplication fork reversal
GO_0031297Biological processreplication fork processing
GO_0009411Biological processresponse to UV
GO_0006281Biological processDNA repair
GO_0036292Biological processDNA rewinding
GO_0006338Biological processchromatin remodeling
GO_0045910Biological processnegative regulation of DNA recombination
GO_0043596Cellular componentnuclear replication fork
GO_0005654Cellular componentnucleoplasm
GO_0140658Molecular functionATP-dependent chromatin remodeler activity
GO_0003678Molecular functionDNA helicase activity
GO_0070530Molecular functionK63-linked polyubiquitin modification-dependent protein binding
GO_0005515Molecular functionprotein binding
GO_0008270Molecular functionzinc ion binding
GO_0036310Molecular functionATP-dependent DNA/DNA annealing activity
GO_0004520Molecular functionDNA endonuclease activity
GO_0005524Molecular functionATP binding

IV. Literature review

[source]
Gene nameZRANB3
Protein nameZinc finger RANBP2-type containing 3
DNA annealing helicase and endonuclease ZRANB3 (Annealing helicase 2) (AH2) (Zinc finger Ran-binding domain-containing protein 3) [Includes: DNA annealing helicase ZRANB3 (EC 3.6.4.-); Endonuclease ZRANB3 (EC 3.1.-.-)]
Zinc finger RANBP2-type containing 3 (Zinc finger, RAN-binding domain containing 3, isoform CRA_g)
SynonymshCG_1643600
DescriptionFUNCTION: DNA annealing helicase and endonuclease required to maintain genome stability at stalled or collapsed replication forks by facilitating fork restart and limiting inappropriate recombination that could occur during template switching events . Recruited to the sites of stalled DNA replication by polyubiquitinated PCNA and acts as a structure-specific endonuclease that cleaves the replication fork D-loop intermediate, generating an accessible 3'-OH group in the template of the leading strand, which is amenable to extension by DNA polymerase . In addition to endonuclease activity, also catalyzes the fork regression via annealing helicase activity in order to prevent disintegration of the replication fork and the formation of double-strand breaks . .

AccessionsENST00000264159.11 [Q5FWF4-1]
F5GYN7
ENST00000401392.5 [Q5FWF4-3]
ENST00000536680.5
Q5FWF4
ENST00000403017.2
F8WCT9
ENST00000619650.4 [Q5FWF4-2]