ZNRF4 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNRF4 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of ZNRF4 at tissue level.

III. Associated gene sets

GO_0016567Biological processprotein ubiquitination
GO_0006511Biological processubiquitin-dependent protein catabolic process
GO_0070433Biological processnegative regulation of nucleotide-binding oligomerization domain containing 2 signaling pathway
GO_0045786Biological processnegative regulation of cell cycle
GO_0043161Biological processproteasome-mediated ubiquitin-dependent protein catabolic process
GO_0005737Cellular componentcytoplasm
GO_0005783Cellular componentendoplasmic reticulum
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0061630Molecular functionubiquitin protein ligase activity
GO_0005515Molecular functionprotein binding
GO_0046872Molecular functionmetal ion binding

IV. Literature review

[source]
Gene nameZNRF4
Protein nameE3 ubiquitin-protein ligase ZNRF4 (EC 2.3.2.27) (Nixin) (RING finger protein 204) (RING-type E3 ubiquitin transferase ZNRF4) (Zinc/RING finger protein 4)
SynonymsRNF204
DescriptionFUNCTION: E3 ubiquitin-protein ligase that acts as a negative regulator of NOD2 signaling by mediating ubiquitination and degradation of RIPK2 . Also catalyzes ubiquitination and proteasomal degradation of CANX within the endoplasmic reticulum . Could have a role in spermatogenesis (By similarity). .

AccessionsENST00000222033.6
Q8WWF5