ZNF658 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of ZNF658 at single-cell level.

II. Expression across tissues

III. Associated gene sets

GO_0071294Biological processcellular response to zinc ion
GO_0042254Biological processribosome biogenesis
GO_0045892Biological processnegative regulation of DNA-templated transcription
GO_0045944Biological processpositive regulation of transcription by RNA polymerase II
GO_0006357Biological processregulation of transcription by RNA polymerase II
GO_0005634Cellular componentnucleus
GO_0000978Molecular functionRNA polymerase II cis-regulatory region sequence-specific DNA binding
GO_0001228Molecular functionDNA-binding transcription activator activity, RNA polymerase II-specific
GO_0046872Molecular functionmetal ion binding
GO_0000976Molecular functiontranscription cis-regulatory region binding

IV. Literature review

[source]
Gene nameZNF658
Protein nameZNF658 protein
Alternative protein ZNF658
Zinc finger protein 658
Synonyms
DescriptionFUNCTION: Mediates transcriptional repression in response to zinc. Represses several genes, including SLC30A5, SLC30A10 and CBWD1, by binding to the zinc transcriptional regulatory element (ZTRE) (5'-C[AC]C[TAG]CC[TC]-N(0-50)-[GA]G[ATC]G[TG]G-3') found in the promoter region. May play a role in the control of ribosome biogenesis, regulating predominantly rRNA levels, as well as those of several ribosomal proteins, thus coordinating this highly zinc-demanding process with the available zinc supply. .

AccessionsA0A087X186
Q5TYW1
ENST00000619925.4
A0A087WVA2
L8E9H6
ENST00000622180.4 [Q5TYW1-2]
ENST00000616544.4
B9EH69
ENST00000621410.5 [Q5TYW1-1]
A0A087WZ36
ENST00000612867.4 [Q5TYW1-1]
A0A087X0H1
ENST00000619435.1
ENST00000621015.4