ZFYVE27 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0045773Biological processpositive regulation of axon extension
GO_0071787Biological processendoplasmic reticulum tubular network formation
GO_0048011Biological processneurotrophin TRK receptor signaling pathway
GO_0031175Biological processneuron projection development
GO_0016192Biological processvesicle-mediated transport
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0071782Cellular componentendoplasmic reticulum tubular network
GO_0055038Cellular componentrecycling endosome membrane
GO_0005654Cellular componentnucleoplasm
GO_0030425Cellular componentdendrite
GO_0005783Cellular componentendoplasmic reticulum
GO_0005829Cellular componentcytosol
GO_0043231Cellular componentintracellular membrane-bounded organelle
GO_0032584Cellular componentgrowth cone membrane
GO_0030424Cellular componentaxon
GO_0042802Molecular functionidentical protein binding
GO_0046872Molecular functionmetal ion binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZFYVE27
Protein nameProtrudin (Spastic paraplegia 33 protein) (Zinc finger FYVE domain-containing protein 27)
Protrudin (Zinc finger FYVE domain-containing protein 27)
SynonymsSPG33
DescriptionFUNCTION: Key regulator of RAB11-dependent vesicular trafficking during neurite extension through polarized membrane transport . Promotes axonal elongation and contributes to the establishment of neuronal cell polarity (By similarity). Involved in nerve growth factor-induced neurite formation in VAPA-dependent manner . Contributes to both the formation and stabilization of the tubular ER network . Involved in ER morphogenesis by regulating the sheet-to-tubule balance and possibly the density of tubule interconnections . Acts as an adapter protein and facilitates the interaction of KIF5A with VAPA, VAPB, SURF4, RAB11A, RAB11B and RTN3 and the ZFYVE27-KIF5A complex contributes to the transport of these proteins in neurons. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a KIF5A/B-dependent manner . .

AccessionsENST00000337540.11 [Q5T4F4-8]
ENST00000393677.8 [Q5T4F4-1]
ENST00000684270.1 [Q5T4F4-1]
Q5T4F4
ENST00000370613.7 [Q5T4F4-6]
A0A0S2Z5V0
ENST00000359980.5 [Q5T4F4-2]
ENST00000423811.3 [Q5T4F4-3]
ENST00000357540.8 [Q5T4F4-5]
A0A0S2Z627
ENST00000370610.7 [Q5T4F4-7]