ZFYVE1 | OmnibusX

Name	Number of supported studies	Average coverage
brain	4 studies	27% ± 6%	Explore

Tissue	GTEx Coverage	GTEx Average TPM	GTEx Number of samples	TCGA Coverage	TCGA Average TPM	TCGA Number of samples
esophagus	100%	2227.47	1445 / 1445	100%	16.42	183 / 183
prostate	100%	1814.10	245 / 245	100%	17.16	502 / 502
skin	100%	2526.73	1808 / 1809	100%	32.71	472 / 472
thymus	100%	2528.64	653 / 653	100%	25.10	604 / 605
brain	100%	1511.86	2637 / 2642	100%	26.65	705 / 705
kidney	100%	1923.51	89 / 89	100%	20.30	897 / 901
breast	100%	2190.29	459 / 459	100%	23.05	1113 / 1118
uterus	100%	1934.75	170 / 170	99%	15.96	455 / 459
lung	100%	1843.14	578 / 578	99%	15.13	1143 / 1155
stomach	100%	1340.36	359 / 359	99%	10.99	282 / 286
bladder	100%	2016.10	21 / 21	98%	13.53	496 / 504
adrenal gland	100%	2841.32	258 / 258	98%	20.72	226 / 230
liver	100%	1256.35	226 / 226	97%	11.34	394 / 406
ovary	100%	1572.90	180 / 180	97%	12.63	417 / 430
intestine	100%	2030.94	966 / 966	97%	10.68	511 / 527
pancreas	97%	739.27	318 / 328	99%	17.02	176 / 178
adipose	100%	2288.90	1204 / 1204	0%	0	0 / 0
blood vessel	100%	2229.56	1335 / 1335	0%	0	0 / 0
eye	0%	0	0 / 0	100%	32.28	80 / 80
lymph node	0%	0	0 / 0	100%	15.74	29 / 29
muscle	100%	1963.37	803 / 803	0%	0	0 / 0
spleen	100%	1800.95	241 / 241	0%	0	0 / 0
tonsil	0%	0	0 / 0	100%	17.54	45 / 45
ureter	0%	0	0 / 0	100%	5.22	1 / 1
peripheral blood	98%	1382.22	914 / 929	0%	0	0 / 0
heart	98%	1150.19	846 / 861	0%	0	0 / 0
abdomen	0%	0	0 / 0	0%	0	0 / 0
bone marrow	0%	0	0 / 0	0%	0	0 / 0
diaphragm	0%	0	0 / 0	0%	0	0 / 0
gingiva	0%	0	0 / 0	0%	0	0 / 0
nasal cavity	0%	0	0 / 0	0%	0	0 / 0
nasopharynx	0%	0	0 / 0	0%	0	0 / 0
nose	0%	0	0 / 0	0%	0	0 / 0
placenta	0%	0	0 / 0	0%	0	0 / 0
spinal column	0%	0	0 / 0	0%	0	0 / 0

GO_0044829	Biological process	positive regulation by host of viral genome replication
GO_0140042	Biological process	lipid droplet formation
GO_0016236	Biological process	macroautophagy
GO_0009267	Biological process	cellular response to starvation
GO_0005795	Cellular component	Golgi stack
GO_0097629	Cellular component	extrinsic component of omegasome membrane
GO_0005811	Cellular component	lipid droplet
GO_0048471	Cellular component	perinuclear region of cytoplasm
GO_0016020	Cellular component	membrane
GO_0005789	Cellular component	endoplasmic reticulum membrane
GO_0005739	Cellular component	mitochondrion
GO_1990462	Cellular component	omegasome
GO_0005794	Cellular component	Golgi apparatus
GO_0044233	Cellular component	mitochondria-associated endoplasmic reticulum membrane contact site
GO_0005783	Cellular component	endoplasmic reticulum
GO_0000407	Cellular component	phagophore assembly site
GO_0005776	Cellular component	autophagosome
GO_0005547	Molecular function	phosphatidylinositol-3,4,5-trisphosphate binding
GO_0032266	Molecular function	phosphatidylinositol-3-phosphate binding
GO_0005545	Molecular function	1-phosphatidylinositol binding
GO_0008270	Molecular function	zinc ion binding
GO_0005515	Molecular function	protein binding
GO_0043325	Molecular function	phosphatidylinositol-3,4-bisphosphate binding

Gene name	ZFYVE1
Protein name	Zinc finger FYVE domain-containing protein 1 (Double FYVE-containing protein 1) (SR3) (Tandem FYVE fingers-1) Zinc finger FYVE-type containing 1
Synonyms	PP10436 ZNFN2A1 DFCP1 TAFF1 KIAA1589
Description	FUNCTION: Plays a role in the formation of lipid droplets (LDs) which are storage organelles at the center of lipid and energy homeostasis . Regulates the morphology, size and distribution of LDs . Mediates the formation of endoplasmic reticulum-lipid droplets (ER-LD) contacts by forming a complex with RAB18 and ZW10 . Binds to phosphatidylinositol 3-phosphate (PtdIns3P) through FYVE-type zinc finger . .; FUNCTION: (Microbial infection) Upon SARS coronavirus-2/SARS-CoV-2 infection, mediates through binding with non-structural protein 6 (nsp6) the replication organelle-lipid droplet association required to sustain viral replication. .
Accessions	ENST00000553891.5 G3V5N8 ENST00000556143.6 [Q9HBF4-1] ENST00000555072.1 [Q9HBF4-2] ENST00000394207.6 [Q9HBF4-2] Q9HBF4 ENST00000318876.9 [Q9HBF4-3]

ZFYVE1 report