ZDHHC7 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0072659Biological processprotein localization to plasma membrane
GO_0009895Biological processnegative regulation of catabolic process
GO_0050847Biological processprogesterone receptor signaling pathway
GO_0150106Biological processregulation of protein localization to cell-cell junction
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_0044381Biological processglucose import in response to insulin stimulus
GO_1902044Biological processregulation of Fas signaling pathway
GO_0008277Biological processregulation of G protein-coupled receptor signaling pathway
GO_0043401Biological processsteroid hormone receptor signaling pathway
GO_0018345Biological processprotein palmitoylation
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_0030521Biological processandrogen receptor signaling pathway
GO_0030859Biological processpolarized epithelial cell differentiation
GO_0005654Cellular componentnucleoplasm
GO_0005794Cellular componentGolgi apparatus
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0019705Molecular functionprotein-cysteine S-myristoyltransferase activity
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC7
Protein namePalmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC7 (EC 2.3.1.225) (Acyltransferase ZDHHC7) (EC 2.3.1.-) (Zinc finger DHHC domain-containing protein 7) (DHHC-7)
Zinc finger DHHC-type palmitoyltransferase 7
Synonyms
DescriptionFUNCTION: Golgi-localized palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and therefore functions in several unrelated biological processes . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). Palmitoylates sex steroid hormone receptors, including ESR1, PGR and AR, thereby regulating their targeting to the plasma membrane and their function in rapid intracellular signaling upon binding of sex hormones . Palmitoylates GNAQ, a heterotrimeric G protein, regulating its dynamic localization at the plasma membrane and is thereby involved in GNAQ-dependent G protein-coupled receptor signaling pathways . Functions also in ligand-induced cell death by regulating the FAS signaling pathway through the palmitoylation and stabilization of the receptor at the plasma membrane . In epithelial cells, palmitoylates SCRIB and regulates its localization to the plasma membrane, regulating indirectly cell polarity and differentiation . Also palmitoylates JAM3 and promotes its expression at tight junctions and regulates its function in cell migration . Palmitoylates the glucose transporter GLUT4/SLC2A4 and controls the insulin-dependent translocation of GLUT4 to the plasma membrane (By similarity). In brain, could also palmitoylate SNAP25 and DLG4/PSD95 (By similarity). Could also palmitoylate DNAJC5 and regulate its localization to the Golgi membrane (By similarity). Could also palmitoylate NCDN (By similarity). May play a role in follicle stimulation hormone (FSH) activation of testicular Sertoli cells (By similarity). .

AccessionsENST00000564466.5 [Q9NXF8-2]
ENST00000313732.9 [Q9NXF8-1]
ENST00000569017.1
Q9NXF8
H3BMI0
H3BNQ9
ENST00000566909.1
ENST00000344861.9 [Q9NXF8-2]