ZDHHC6 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018345Biological processprotein palmitoylation
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0140438Biological processprotein stearoylation
GO_0006612Biological processprotein targeting to membrane
GO_0010636Biological processpositive regulation of mitochondrial fusion
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZDHHC6
Protein nameprotein S-acyltransferase (EC 2.3.1.225)
Alternative protein ZDHHC6
Palmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC6 (EC 2.3.1.225) (Stearoyltransferase ZDHHC6) (EC 2.3.1.-) (Transmembrane protein H4) (Zinc finger DHHC domain-containing protein 6) (DHHC-6) (Zinc finger protein 376)
SynonymshCG_40976
ZNF376
DescriptionFUNCTION: Endoplasmic reticulum palmitoyl acyltransferase that mediates palmitoylation of proteins such as AMFR, CALX, ITPR1 and TFRC . Palmitoylates calnexin (CALX), which is required for its association with the ribosome-translocon complex and efficient folding of glycosylated proteins . Mediates palmitoylation of AMFR, promoting AMFR distribution to the peripheral endoplasmic reticulum . Together with SELENOK, palmitoylates ITPR1 in immune cells, leading to regulate ITPR1 stability and function . Stearoyltransferase that mediates stearoylation of TFRC to inhibit TFRC-mediated activation of the JNK pathway and mitochondrial fragmentation . .

AccessionsENST00000682616.1
ENST00000683895.1 [Q9H6R6-1]
A0A804HJ80
ENST00000626395.2
ENST00000683319.1
ENST00000682731.1
A0A804HKZ7
A0A804HL82
ENST00000684507.1 [Q9H6R6-1]
ENST00000681964.1
ENST00000682055.1
ENST00000682195.1
A0A804HJC7
ENST00000369404.3 [Q9H6R6-2]
A0A0D9SEX5
A0A804HL63
ENST00000683505.1
A0A804HJK5
Q9H6R6
L8E944
ENST00000684173.1
ENST00000684741.1
ENST00000369405.7 [Q9H6R6-1]
ENST00000682267.1
ENST00000682839.1
A0A804HJ40