ZDHHC2 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0042176Biological processregulation of protein catabolic process
GO_0072659Biological processprotein localization to plasma membrane
GO_1903539Biological processprotein localization to postsynaptic membrane
GO_0022407Biological processregulation of cell-cell adhesion
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_1903044Biological processprotein localization to membrane raft
GO_0006612Biological processprotein targeting to membrane
GO_0048168Biological processregulation of neuronal synaptic plasticity
GO_1900273Biological processpositive regulation of long-term synaptic potentiation
GO_0019538Biological processprotein metabolic process
GO_0018345Biological processprotein palmitoylation
GO_0007416Biological processsynapse assembly
GO_1903076Biological processregulation of protein localization to plasma membrane
GO_1905751Biological processpositive regulation of endosome to plasma membrane protein transport
GO_1904719Biological processpositive regulation of AMPA glutamate receptor clustering
GO_0005886Cellular componentplasma membrane
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0055038Cellular componentrecycling endosome membrane
GO_0005794Cellular componentGolgi apparatus
GO_0098837Cellular componentpostsynaptic recycling endosome
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0014069Cellular componentpostsynaptic density
GO_0098944Cellular componentpostsynaptic recycling endosome membrane
GO_0042803Molecular functionprotein homodimerization activity
GO_0019705Molecular functionprotein-cysteine S-myristoyltransferase activity
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0140439Molecular functionprotein-cysteine S-stearoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC2
Protein nameZinc finger DHHC-type palmitoyltransferase 2
Palmitoyltransferase ZDHHC2 (EC 2.3.1.225) (Acyltransferase ZDHHC2) (EC 2.3.1.-) (Reduced expression associated with metastasis protein) (Ream) (Reduced expression in cancer protein) (Rec) (Zinc finger DHHC domain-containing protein 2) (DHHC-2) (Zinc finger protein 372)
Palmitoyltransferase (EC 2.3.1.225)
SynonymsREC
ZNF372
REAM
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates and is involved in a variety of cellular processes . Has no stringent fatty acid selectivity and in addition to palmitate can also transfer onto target proteins myristate from tetradecanoyl-CoA and stearate from octadecanoyl-CoA (By similarity). In the nervous system, plays a role in long term synaptic potentiation by palmitoylating AKAP5 through which it regulates protein trafficking from the dendritic recycling endosomes to the plasma membrane and controls both structural and functional plasticity at excitatory synapses (By similarity). In dendrites, mediates the palmitoylation of DLG4 when synaptic activity decreases and induces synaptic clustering of DLG4 and associated AMPA-type glutamate receptors (By similarity). Also mediates the de novo and turnover palmitoylation of RGS7BP, a shuttle for Gi/o-specific GTPase-activating proteins/GAPs, promoting its localization to the plasma membrane in response to the activation of G protein-coupled receptors. Through the localization of these GTPase-activating proteins/GAPs, it also probably plays a role in G protein-coupled receptors signaling in neurons (By similarity). Also probably plays a role in cell adhesion by palmitoylating CD9 and CD151 to regulate their expression and function . Palmitoylates the endoplasmic reticulum protein CKAP4 and regulates its localization to the plasma membrane . Could also palmitoylate LCK and regulate its localization to the plasma membrane . .; FUNCTION: (Microbial infection) Promotes Chikungunya virus (CHIKV) replication by mediating viral nsp1 palmitoylation. .

AccessionsE5RFZ7
ENST00000522184.1
ENST00000262096.13
A0A1Y8EM58
ENST00000523132.1
Q9UIJ5