ZDHHC18 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0045824Biological processnegative regulation of innate immune response
GO_0160049Biological processnegative regulation of cGAS/STING signaling pathway
GO_0018345Biological processprotein palmitoylation
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0006612Biological processprotein targeting to membrane
GO_0045087Biological processinnate immune response
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC18
Protein nameZinc finger DHHC-type palmitoyltransferase 18
Palmitoyltransferase ZDHHC18 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 18) (DHHC-18) (Zinc finger DHHC domain-containing protein 18)
Palmitoyltransferase (EC 2.3.1.225)
Synonyms
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates, such as CGAS, HRAS and LCK . Acts as a negative regulator of the cGAS-STING pathway be mediating palmitoylation and inactivation of CGAS . May also have a palmitoyltransferase activity toward the beta-2 adrenergic receptor/ADRB2 and therefore regulate G protein-coupled receptor signaling . .

AccessionsENST00000488397.3
ENST00000374142.9 [Q9NUE0-1]
H0YEN1
ENST00000534643.5
ENST00000374141.6 [Q9NUE0-2]
E9PJS3
Q9NUE0