ZDHHC12 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018345Biological processprotein palmitoylation
GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0032230Biological processpositive regulation of synaptic transmission, GABAergic
GO_0006612Biological processprotein targeting to membrane
GO_0097116Biological processgephyrin clustering involved in postsynaptic density assembly
GO_1900226Biological processnegative regulation of NLRP3 inflammasome complex assembly
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0016409Molecular functionpalmitoyltransferase activity
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity

IV. Literature review

[source]
Gene nameZDHHC12
Protein namePalmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC12 (EC 2.3.1.225) (DHHC domain-containing cysteine-rich protein 12) (DHHC-12) (Zinc finger DHHC domain-containing protein 12) (Zinc finger protein 400)
SynonymsZNF400
PSEC0008
DescriptionFUNCTION: Palmitoyltransferase that catalyzes the addition of palmitate onto various protein substrates . Has a palmitoyltransferase activity toward gephyrin/GPHN, regulating its clustering at synapses and its function in gamma-aminobutyric acid receptor clustering (By similarity). Thereby, indirectly regulates GABAergic synaptic transmission (By similarity). Acts as an inhibitor of the NLRP3 inflammasome by mediating palmitoylation of NLRP3, thereby promoting NLRP3 degradation by the chaperone-mediated autophagy (CMA) process . .

AccessionsQ5T266
ENST00000452105.5
ENST00000372663.9 [Q96GR4-1]
Q5T269
ENST00000406904.2
ENST00000372667.9
Q96GR4
X6RBN4