ZDHHC11 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0018230Biological processpeptidyl-L-cysteine S-palmitoylation
GO_0140374Biological processantiviral innate immune response
GO_0006612Biological processprotein targeting to membrane
GO_0002230Biological processpositive regulation of defense response to virus by host
GO_0010008Cellular componentendosome membrane
GO_0000139Cellular componentGolgi membrane
GO_0005783Cellular componentendoplasmic reticulum
GO_0005794Cellular componentGolgi apparatus
GO_0005789Cellular componentendoplasmic reticulum membrane
GO_0019706Molecular functionprotein-cysteine S-palmitoyltransferase activity
GO_0035591Molecular functionsignaling adaptor activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameZDHHC11
Protein nameZinc finger DHHC-type containing 11
Palmitoyltransferase (EC 2.3.1.225)
Palmitoyltransferase ZDHHC11 (EC 2.3.1.225) (Zinc finger DHHC domain-containing protein 11) (DHHC-11) (Zinc finger protein 399)
SynonymsZNF399
DescriptionFUNCTION: Endoplasmic reticulum-localized palmitoyltransferase that could catalyze the addition of palmitate onto various protein substrates and be involved in a variety of cellular processes (By similarity). Has a palmitoyltransferase activity toward NCDN and regulates NCDN association with endosome membranes through this palmitoylation (By similarity). May play a role in cell proliferation . .; FUNCTION: Has also a palmitoyltransferase activity-independent function in DNA virus-triggered and CGAS-mediated innate immune response . Functions as an adapter that recruits IRF3 to STING1 to promote the activation of that key transcriptional regulator of type I interferon (IFN)-dependent immune response . .

AccessionsD6RE92
ENST00000507800.1
ENST00000511193.1
H0Y9D0
ENST00000685990.1
A0A8I5KQG6
Q9H8X9
ENST00000283441.13 [Q9H8X9-1]
ENST00000511539.1 [Q9H8X9-2]