YTHDF1 report

I. Expression across cell types

II. Expression across tissues

III. Associated gene sets

GO_0070925Biological processorganelle assembly
GO_0002376Biological processimmune system process
GO_0045948Biological processpositive regulation of translational initiation
GO_0034063Biological processstress granule assembly
GO_1900271Biological processregulation of long-term synaptic potentiation
GO_0043488Biological processregulation of mRNA stability
GO_0007612Biological processlearning
GO_0061157Biological processmRNA destabilization
GO_0002577Biological processregulation of antigen processing and presentation
GO_1902667Biological processregulation of axon guidance
GO_0045727Biological processpositive regulation of translation
GO_0007613Biological processmemory
GO_0000932Cellular componentP-body
GO_0005737Cellular componentcytoplasm
GO_0010494Cellular componentcytoplasmic stress granule
GO_0043022Molecular functionribosome binding
GO_0003729Molecular functionmRNA binding
GO_1990247Molecular functionN6-methyladenosine-containing RNA reader activity
GO_0003723Molecular functionRNA binding
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYTHDF1
Protein nameAlternative protein YTHDF1
YTH N6-methyladenosine RNA binding protein 1
YTH domain-containing family protein 1 (DF1) (Dermatomyositis associated with cancer putative autoantigen 1) (DACA-1)
SynonymsC20orf21
DescriptionFUNCTION: Specifically recognizes and binds N6-methyladenosine (m6A)-containing mRNAs, and regulates their stability . M6A is a modification present at internal sites of mRNAs and some non-coding RNAs and plays a role in mRNA stability and processing . Acts as a regulator of mRNA stability by promoting degradation of m6A-containing mRNAs via interaction with the CCR4-NOT complex . The YTHDF paralogs (YTHDF1, YTHDF2 and YTHDF3) shares m6A-containing mRNAs targets and act redundantly to mediate mRNA degradation and cellular differentiation . Required to facilitate learning and memory formation in the hippocampus by binding to m6A-containing neuronal mRNAs (By similarity). Acts as a regulator of axon guidance by binding to m6A-containing ROBO3 transcripts (By similarity). Acts as a negative regulator of antigen cross-presentation in myeloid dendritic cells (By similarity). In the context of tumorigenesis, negative regulation of antigen cross-presentation limits the anti-tumor response by reducing efficiency of tumor-antigen cross-presentation (By similarity). Promotes formation of phase-separated membraneless compartments, such as P-bodies or stress granules, by undergoing liquid-liquid phase separation upon binding to mRNAs containing multiple m6A-modified residues: polymethylated mRNAs act as a multivalent scaffold for the binding of YTHDF proteins, juxtaposing their disordered regions and thereby leading to phase separation . The resulting mRNA-YTHDF complexes then partition into different endogenous phase-separated membraneless compartments, such as P-bodies, stress granules or neuronal RNA granules . .

AccessionsL8EA03
ENST00000370334.4
Q9BYJ9
ENST00000370339.8 [Q9BYJ9-1]
Q5JXC6