YJEFN3 report

I. Expression across cell types

Insufficient scRNA-seq data for expression of YJEFN3 at single-cell level.

II. Expression across tissues

sc-RNAseq data

Insufficient scRNA-seq data for expression of YJEFN3 at tissue level.

III. Associated gene sets

GO_0008593Biological processregulation of Notch signaling pathway
GO_0010874Biological processregulation of cholesterol efflux
GO_0016525Biological processnegative regulation of angiogenesis
GO_0071425Biological processhematopoietic stem cell proliferation
GO_0031580Biological processmembrane raft distribution
GO_0006869Biological processlipid transport
GO_0002040Biological processsprouting angiogenesis
GO_0052856Molecular functionNADHX epimerase activity
GO_0005515Molecular functionprotein binding

IV. Literature review

[source]
Gene nameYJEFN3
Protein nameYjeF N-terminal domain containing 3
FLJ44968 protein, isoform CRA_c (YJEFN3 protein) (cDNA FLJ44968 fis, clone BRAWH2016562)
YjeF N-terminal domain-containing protein 3 (YjeF_N3) (hYjeF_N3) (ApoA-I-binding protein 2)
SynonymsAIBP2
FLJ44968
hCG_1641546
DescriptionFUNCTION: May accelerate cholesterol efflux from endothelial cells to high-density lipoprotein (HDL) and thereby regulates angiogenesis. May orchestrate hematopoietic stem and progenitor cell emergence from the hemogenic endothelium, a type of specialized endothelium manifesting hematopoietic potential. YJEFN3-mediated cholesterol efflux activates endothelial SREBF2, the master transcription factor for cholesterol biosynthesis, which in turn transactivates NOTCH and promotes hematopoietic stem and progenitor cell emergence (By similarity). May play a role in spermiogenesis and oogenesis . .

AccessionsA0A087WUA6
ENST00000458210.7
ENST00000436027.9 [A6XGL0-2]
Q6ZT45
ENST00000514277.6 [A6XGL0-1]
A6XGL0